The essentials of developmental apoptosis

F1000Research
Anne K Voss, Andreas Strasser

Abstract

Apoptotic cells are commonly observed in a broad range of tissues during mammalian embryonic and fetal development. Specific requirements and functions of programmed cell death were inferred from early observations. These inferences did not hold up to functional proof for a requirement of apoptosis for normal tissue development in all cases. In this review, we summarize how the appraisal of the importance of developmental apoptosis has changed over the years, in particular with detailed functional assessment, such as by using gene-targeted mice lacking essential initiators or mediators of apoptosis. In recent years, the essentials of developmental apoptosis have emerged. We hypothesize that apoptosis is predominantly required to balance cell proliferation. The two interdependent processes-cell proliferation and apoptosis-together more powerfully regulate tissue growth than does each process alone. We proposed that this ensures that tissues and cell populations attain the appropriate size that allows fusion in the body midline and retain the size of cavities once formed. In addition, a limited number of tissues, albeit not all previously proposed, rely on apoptosis for remodeling, chiefly aortic arch remodeling, elimination of s...Continue Reading

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Citations

Dec 21, 2020·Environment International·Yingya ZhaoYunhui Zhang
Jan 14, 2021·The EMBO Journal·Matthias Kist, Domagoj Vucic
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Juan A MonteroJuan M Hurle
Jan 5, 2021·Frontiers in Cell and Developmental Biology·Priscila Ramos-IbeasEnrique Gómez
Nov 15, 2020·Nature Reviews. Immunology·Carla V RothlinSourav Ghosh
Mar 7, 2021·International Journal of Molecular Sciences·Zbigniew WyżewskiKarolina Paulina Gregorczyk-Zboroch
Jul 1, 2020·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Nir Shahar, Sarit Larisch
Aug 18, 2021·IScience·Ruoyao ChenMichael Overholtzer
Aug 28, 2021·Nutrients·Ewa Forma, Magdalena Bryś
Nov 3, 2021·Cell Death & Disease·Jiayin DengLaura Senovilla
Nov 9, 2021·Biochemical Society Transactions·João Pessoa

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Methods Mentioned

BETA
electron microscopy
flow cytometry

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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