The estimation of post-transplant lymphocele origin using creatine kinase activity.

Upsala Journal of Medical Sciences
J PacovskýMilos Brodak

Abstract

The aim of this research was to create a laboratory instrument for the estimation of post-transplant lymphocele origin. It is based on the enzymatic activity of creatine kinase (CK) in the lymphocele content. A total of 120 lymph samples from different retroperitoneal regions were obtained from non-transplanted patients; equal numbers from the iliac region, renal cysts, and the subdiaphragmatic retroperitoneum. Activities of creatine kinase (CK) and gamma-glutamyl transpeptidase (GGT) were determined in all samples and statistically analyzed against their activity in serum from patients without surgery. Activities of CK in the pelvis, retroperitoneum, renal cysts, and serum were 5.06, 0.83, 6.48 (P<0.001), 2.50, 0.73, 3.60 (P<0.001), 0.02, 0.01, 0.05 (P<0.001), and 0.66, 0.41, 0.79 microkat/l, respectively. Activities of GGT in the same lymph samples were 0.26, 0.16, 0.36 (P=0.048), 0.41, 0.25, 0.48 (non-significant), 0.11, 0.07, 1.17 (P=0.003) and 0.34, 0.24, 0.55 microkat/l, respectively. A graph was constructed relating CK activity to lymph origin. Significantly different CK enzyme activity was observed in different regions of the retroperitoneum. The presented graph is a simple instrument for the estimation of the lymphocel...Continue Reading

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Citations

Sep 29, 2015·Clinical Kidney Journal·Andrea RanghinoLuigi Biancone
Aug 9, 2016·Transplantation Proceedings·B BzomaB Rutkowski
Oct 11, 2016·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·M-O TimsitR Thuret
Sep 6, 2020·Journal of Clinical Medicine·Lukas J LehnerMichael Duerr

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