PMID: 7084562Apr 1, 1982Paper

The estrogen-induced vitellogenin synthesis in chicken liver after estrogen withdrawal or antiestrogen treatment

Molecular and Cellular Endocrinology
M GschwendtT Schuster

Abstract

(1) The induction of vitellogenin synthesis in chicken liver by an estrogen implant as well as the decline of vitellogenin synthesis and nuclear receptor concentration after withdrawal of the implant were studied. For the detection of vitellogenin the SAC immunoprecipitation technique was used. The nuclear receptor decreases very rapidly and somewhat earlier than the capacity of the liver to synthesize vitellogenin. (2) The inhibition by antiestrogens of the estrogen-induced vitellogenin synthesis as well as of the accumulation of the estrogen-receptor complex in the nucleus was investigated. Tamoxifen as well as the recently described 1,1,2,2-tetramethyl-1,2-bis(4'-hydroxyphenyl)ethane were found to be true antiestrogens in the chicken liver, i.e. they inhibit estrogen-induced vitellogenin synthesis but themselves cause no induction.

References

Apr 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A T BurnsR F Goldberger
Dec 14, 1979·Biochemical and Biophysical Research Communications·N BinartE E Baulieu
Dec 1, 1977·Hoppe-Seyler's Zeitschrift für physiologische Chemie·W Schneider, M Gschwendt
Jun 2, 1977·Nature·R SutherlandE E Baulieu
Feb 12, 1981·Biochemical and Biophysical Research Communications·M L Blue, D L Williams
Oct 1, 1980·Molecular and Cellular Endocrinology·J L Borgna, H Rochefort

Related Concepts

Estrogen Antagonists
Estrogen Effect
Lipoproteins
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Estrogen Nuclear Receptor
Zitazonium
Vitellogenin II

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