The estrogen receptor ligand ICI 182,780 does not impair the bone-sparing effects of testosterone in the young orchidectomized rat model

Calcified Tissue International
L VandenputD Vanderschueren

Abstract

Testosterone (T) can affect bone metabolism not only directly, but also via its metabolites, estrogen or dihydrotestosterone, produced by enzymes present in bone. Therefore, the aim of this study was to investigate whether the high-affinity estrogen receptor ligand ICI 182,780 (ICI) impaired the bone-protective action of T in 3-month-old orchidectomized (Orch) rats, studied during an experimental period of 3 months. As expected, Orch significantly decreased trabecular bone volume in the proximal tibial metaphysis (-52%), as measured by histomorphometry, and had a similar negative effect on volumetric bone mineral density (BMD) in the distal femoral metaphysis (-53%), as assessed by peripheral quantitative computed tomography (pQCT). The loss of bone induced by Orch was completely prevented by T administration. Moreover, the Orch-associated increases of biochemical markers of bone turnover (serum osteocalcin, urinary deoxypyridinoline, and calcium excretion) did not occur when Orch rats received T. Administration of ICI in combination with T did not impair this bone-sparing effect. Cortical bone parameters (as determined by pQCT), body weight gain, and body composition (as measured by dual-energy X-ray absorptiometry) were not a...Continue Reading

Citations

Nov 20, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Patricia K RussellRachel A Davey
Aug 18, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Liesbeth VandenputDirk Vanderschueren
May 1, 2010·Journal of Cellular Physiology·Baruch FrenkelYankel Gabet
Dec 10, 2003·Seminars in Oncology·Bhuvaneswari Ramaswamy, Charles L Shapiro
Sep 4, 2019·Alcoholism, Clinical and Experimental Research·Lindsay WagnerRussell T Turner
Apr 9, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity·Peter R Ebeling
Jun 8, 2004·Endocrine Reviews·Dirk VanderschuerenClaes Ohlsson
Sep 16, 2004·American Journal of Physiology. Endocrinology and Metabolism·Stephen E BorstChristine F Conover

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