The estrogenic effect of Pueraria mirifica on gonadotrophin levels in aged monkeys.

Endocrine
Hataitip TrisomboonKazuyoshi Taya

Abstract

We investigated the effect of Pueraria mirifica (PM) on gonadotrophin and estradiol levels in aged animals; nine menopausal cynomolgus monkeys were divided into three groups. Each group (n = 3) was fed with 10, 100, and 1000 mg/d of PM for 90 d. PM-10 induced the decrease of follicle stimulating hormone (FSH) levels on d 15-90 in one out of three monkeys. PM-100 and PM-1000 decreased FSH levels of all monkeys throughout the treatment period. After the treatment period, FSH levels continued to decrease for 5 and 10-20 d in PM-100 and PM-1000, respectively, and the levels rebounded in all groups thereafter. PM-10 decreased luteinizing hormone (LH) levels throughout the treatment period in one out of three monkeys and returned to the pretreatment levels immediately after stopping treatment. PM-100 and PM-1000 prominently decreased LH levels between d 10 and 90 during treatment and persisted until d 15-25 and d 20-30 for PM-100 and PM-1000, respectively, during the post-treatment period. Serum LH levels rebounded after returning to pre-treatment levels in a dose-dependent manner. Estradiol levels tended to decrease during the treatment period in all groups. The daily feeding of PM suppressed gonadotrophin levels in aged menopausal ...Continue Reading

Citations

Mar 31, 2012·Frontiers of Medicine·Suchinda Malaivijitnond
Apr 7, 2007·Menopause : the Journal of the North American Menopause Society·Jittima ManonaiHathai Theppisai
Dec 23, 2008·Menopause : the Journal of the North American Menopause Society·Jittima ManonaiKlaus Peter Jünemann
Jun 27, 2006·The Journal of Reproduction and Development·Hataitip TrisomboonKazuyoshi Taya
Jan 19, 2007·The Journal of Reproduction and Development·Wichai CherdshewasartSuchinda Malaivijitnond
Jan 5, 2007·The Journal of Reproduction and Development·Hataitip TrisomboonKazuyoshi Taya
Jun 23, 2007·The Journal of Reproduction and Development·Sukanya JaroenpornWichai Cherdshewasart
Dec 28, 2007·The Journal of Reproduction and Development·Wichai CherdshewasartPorntipa Picha
Oct 27, 2009·Future Oncology·Menno R VriensOrlo H Clark
Oct 12, 2007·Bioscience, Biotechnology, and Biochemistry·Wichai Cherdshewasart, Suttijit Sriwatcharakul
Feb 2, 2010·Fitoterapia·Suchinda MalaivijitnondNathachit Limjunyawong
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Mar 4, 2008·Maturitas·Nontakorn UrasoponSuchinda Malaivijitnond
Mar 4, 2008·Maturitas·Wichai Cherdshewasart, Suttijit Sriwatcharakul
Sep 25, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·W Cherdshewasart, W Sutjit
Nov 15, 2006·Maturitas·Nontakorn UrasoponSuchinda Malaivijitnond
Feb 27, 2016·Phytotherapy Research : PTR·Kanya AnukulthanakornSuchinda Malaivijitnond
Mar 8, 2012·Toxicology Mechanisms and Methods·Sarawoot GomuttapongSuchinda Malaivijitnond
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Jul 18, 2013·Reproductive Medicine and Biology·Kanya AnukulthanakornSuchinda Malaivijitnond

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