The etiology of osteoarthritis of the hip: an integrated mechanical concept

Clinical Orthopaedics and Related Research
R GanzWilliam H Harris

Abstract

The etiology of osteoarthritis of the hip has long been considered secondary (eg, to congenital or developmental deformities) or primary (presuming some underlying abnormality of articular cartilage). Recent information supports a hypothesis that so-called primary osteoarthritis is also secondary to subtle developmental abnormalities and the mechanism in these cases is femoroacetabular impingement rather than excessive contact stress. The most frequent location for femoroacetabular impingement is the anterosuperior rim area and the most critical motion is internal rotation of the hip in 90 degrees flexion. Two types of femoroacetabular impingement have been identified. Cam-type femoroacetabular impingement, more prevalent in young male patients, is caused by an offset pathomorphology between head and neck and produces an outside-in delamination of the acetabulum. Pincer-type femoroacetabular impingement, more prevalent in middle-aged women, is produced by a more linear impact between a local (retroversion of the acetabulum) or general overcoverage (coxa profunda/protrusio) of the acetabulum. The damage pattern is more restricted to the rim and the process of joint degeneration is slower. Most hips, however, show a mixed femoroa...Continue Reading

Associated Clinical Trials

References

May 1, 1976·The Journal of Bone and Joint Surgery. British Volume·L Solomon
Nov 1, 1965·The British Journal of Radiology·R O Murray
Aug 1, 1984·British Journal of Rheumatology·L Solomon
Apr 1, 1982·Annals of the Rheumatic Diseases·L SolomonJ P Browett
Aug 30, 2000·The Journal of Bone and Joint Surgery. British Volume·E GautierR Ganz
Feb 24, 2001·Acta Orthopaedica Scandinavica·M LeunigR Ganz
Oct 17, 2001·Journal of Orthopaedic Trauma·H EijerR Ganz
Feb 7, 2003·The Journal of Bone and Joint Surgery. American Volume·K A SiebenrockR Ganz
Aug 5, 2003·Clinical Orthopaedics and Related Research·Michael LeunigReinhold Ganz
Mar 27, 2004·Clinical Orthopaedics and Related Research·K A SiebenrockR Ganz
Mar 27, 2004·Clinical Orthopaedics and Related Research·Michael LeunigReinhold Ganz
May 29, 2004·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Marcus JägerRüdiger Krauspe
Dec 4, 2004·Clinical Orthopaedics and Related Research·Stephen MurphyMichael B Millis
Dec 4, 2004·Clinical Orthopaedics and Related Research·Keita ItoReinhold Ganz
Mar 24, 2005·Der Unfallchirurg·A Strehl, R Ganz
Apr 19, 2005·The Orthopedic Clinics of North America·Sean E NorkMichael Leunig
Jun 1, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Paul E BeauléFrederick J Dorey
Sep 1, 2005·Archives of Orthopaedic and Trauma Surgery·Y Vehbi SozenGokcer Uzer
Sep 21, 2005·Skeletal Radiology·Douglas P BeallJon R Fish
Nov 2, 2005·The Journal of Bone and Joint Surgery. British Volume·J R Crawford, R N Villar
Nov 9, 2005·Magnetic Resonance Imaging Clinics of North America·Miriam A Bredella, David W Stoller
Dec 3, 2005·Der Orthopäde·M Wettstein, M Dienst
Dec 27, 2005·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Brian T KellyMarc J Philippon
Jan 10, 2006·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Carlos A Guanche, Aaron A Bare
Feb 4, 2006·Clinical Orthopaedics and Related Research·Dominik C MeyerMichael Leunig
Mar 23, 2006·Skeletal Radiology·Donna G Blankenbaker, Michael J Tuite
Apr 28, 2006·Clinics in Sports Medicine·Derek R ArmfieldDouglas D Robertson
Apr 28, 2006·Clinics in Sports Medicine·Srino Bharam
Apr 28, 2006·Clinics in Sports Medicine·Marc J Philippon, Mara L Schenker
Apr 28, 2006·Clinics in Sports Medicine·Marc J Philippon, Mara L Schenker
May 3, 2006·The Journal of Bone and Joint Surgery. American Volume·Norman EspinosaMichael Leunig
May 23, 2006·American Journal of Physical Medicine & Rehabilitation·Steve J Wisniewski, Brian Grogg
Aug 3, 2006·The Journal of Bone and Joint Surgery. American Volume·Christopher L Peters, Jill A Erickson
Feb 12, 2008·Clinical Orthopaedics and Related Research·Fabian KalbererMichael Leunig

❮ Previous
Next ❯

Citations

Jun 17, 2011·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Khaled MeknasJüri Kartus
Aug 10, 2010·International Orthopaedics·Christoph ZilkensRüdiger Krauspe
Jul 30, 2011·Archives of Orthopaedic and Trauma Surgery·Patrick O ZinggClaudio Dora
Apr 9, 2011·Current Reviews in Musculoskeletal Medicine·Purnajyoti Banerjee, Christopher R McLean
Jan 11, 2012·Current Reviews in Musculoskeletal Medicine·Scott SiverlingPeter Moley
Mar 1, 2012·Current Reviews in Musculoskeletal Medicine·Peter DraovitchBryan T Kelly
Mar 1, 2012·Current Reviews in Musculoskeletal Medicine·Jaime EdelsteinPeter Draovitch
Mar 1, 2013·Journal of Biomechanical Engineering·Corinne R HenakJeffrey A Weiss
Aug 27, 2013·AJR. American Journal of Roentgenology·David A Rubin
Jan 31, 2014·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Geoffrey D AbramsGaetano J Scuderi
Feb 22, 2011·The Journal of Orthopaedic and Sports Physical Therapy·Paula M YazbekThiago Yukio Fukuda
Apr 2, 2014·International Orthopaedics·Zeiad Alshameeri, Vikas Khanduja
Aug 24, 2013·Musculoskeletal Surgery·E GenoveseM Giganti
Aug 8, 2014·The Journal of Orthopaedic and Sports Physical Therapy·Robert T LeBeau, Shane J Nho
Jul 1, 2014·Journal of Hip Preservation Surgery·Vickas Khanna, Paul E Beaulé
Oct 10, 2014·The Journal of Orthopaedic and Sports Physical Therapy·Marcie Harris-HayesGretchen B Salsich
May 16, 2013·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Catherine N PetchprapaMichael P Recht
Mar 3, 2011·Clinical Orthopaedics and Related Research·Harold J P van BosseDavid S Feldman
Mar 25, 2016·Journal of Hip Preservation Surgery·Roland S CamenzindMartin Beck
Mar 25, 2016·Journal of Hip Preservation Surgery·Jibanananda SatpathyWilliam A Jiranek
Mar 25, 2016·Journal of Hip Preservation Surgery·Jonathan D Packer, Marc R Safran
Mar 25, 2009·Journal of Children's Orthopaedics·Dennis R Roy
Dec 24, 2015·Frontiers in Surgery·Benjamin D KuhnsLuis Pulido
Mar 31, 2016·Journal of Hip Preservation Surgery·Mikael SansoneRoland Thomeé
Dec 9, 2009·Orthopedics·Debabrata PadhySeung-Beom Han
Jan 8, 2011·Orthopedics·Christopher L PetersJeffrey A Weiss
Mar 11, 2016·Nature Reviews. Rheumatology·Moin KhanMohit Bhandari
Apr 15, 2014·Journal of Orthopaedic Surgery and Research·Kensuke FukushimaMasashi Takaso
Jan 8, 2014·The Bone & Joint Journal·M Leunig, R Ganz
Sep 9, 2015·Frontiers in Surgery·Simon LeeShane J Nho
Aug 11, 2015·Frontiers in Surgery·Bernd BittersohlRüdiger Krauspe
Sep 2, 2016·Journal of Hip Preservation Surgery·Bjarne Mygind-KlavsenMartin Lind
Mar 25, 2016·Journal of Hip Preservation Surgery·Caroline N ParkAnil S Ranawat
Dec 9, 2014·Computer Methods in Biomechanics and Biomedical Engineering·Milad MasjediJustin Cobb
Jan 9, 2015·Computer Methods in Biomechanics and Biomedical Engineering·F L HellwigJ G Hussell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.