The Etiology of Vaginal Discharge Syndrome in Zimbabwe: Results from the Zimbabwe STI Etiology Study

Sexually Transmitted Diseases
Z Mike ChirenjeCornelis A Rietmeijer

Abstract

Symptomatic vaginal discharge is a common gynecological condition managed syndromically in most developing countries. In Zimbabwe, women presenting with symptomatic vaginal discharge are treated with empirical regimens that commonly cover both sexually transmitted infections (STIs) and reproductive tract infections, typically including a combination of an intramuscular injection of kanamycin, and oral doxycycline and metronidazole regimens. This study was conducted to determine the current etiology of symptomatic vaginal discharge and assess adequacy of current syndromic management guidelines. We enrolled 200 women with symptomatic vaginal discharge presenting at 6 STI clinics in Zimbabwe. Microscopy was used to detect bacterial vaginosis and yeast infection. Nucleic acid amplifications tests were used to detect Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, and Mycoplasma genitalium. In addition, serologic testing was performed to detect human immunodeficiency virus (HIV) infection. Of the 200 women, 146 (73%) had an etiology detected, including bacterial vaginosis (24.7%); N. gonorrhoeae (24.0%); yeast infection (20.7%); T. vaginalis (19.0%); C. trachomatis (14.0%) and M. genitalium (7.0%). Among women w...Continue Reading

References

May 29, 2004·BMJ : British Medical Journal·Helen Mitchell
Dec 6, 2005·Sexually Transmitted Infections·J M PickeringP Mayaud
Jan 31, 2007·The Journal of Infectious Diseases·R Scott McClellandJared M Baeten
Feb 25, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Krishna RayM Bhattacharya
Apr 22, 2010·International Journal of Epidemiology·Simon GregsonOwen Mugurungi
Jul 20, 2011·The New England Journal of Medicine·Myron S CohenUNKNOWN HPTN 052 Study Team
Nov 22, 2011·The Journal of Infectious Diseases·Judith VandepitteHeiner Grosskurth
Jul 13, 2012·The New England Journal of Medicine·Jared M BaetenUNKNOWN Partners PrEP Study Team
Jul 13, 2012·The New England Journal of Medicine·Lut Van DammeUNKNOWN FEM-PrEP Study Group
Apr 10, 2013·Asian Pacific Journal of Tropical Biomedicine·Simplice D KarouJacques Simpore
Jul 12, 2013·Obstetrics and Gynecology International·Tânia Maria M V da FonsecaElisabeth B Schmidt
Jun 6, 2014·Sexually Transmitted Infections·M Bradford GuffeyUNKNOWN HIV Prevention Trials Network (HPTN) 035 Study Team
Aug 8, 2014·Journal of Clinical Microbiology·Ayodele Gomih-AlakijaJennifer S Smith
Jul 14, 2017·The Lancet Infectious Diseases·Jørgen Skov Jensen
Dec 15, 2017·Sexually Transmitted Diseases·Cornelis A RietmeijerMufuta Tshimanga

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Citations

Dec 18, 2021·Southern African Journal of Infectious Diseases·Bongekile Ngobese, Nathlee S Abbai

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