Mar 29, 2008

The eukaryotic genome as an RNA machine

Science
Paulo P AmaralJohn S Mattick

Abstract

The past few years have revealed that the genomes of all studied eukaryotes are almost entirely transcribed, generating an enormous number of non-protein-coding RNAs (ncRNAs). In parallel, it is increasingly evident that many of these RNAs have regulatory functions. Here, we highlight recent advances that illustrate the diversity of ncRNA control of genome dynamics, cell biology, and developmental programming.

  • References72
  • Citations289
  • References72
  • Citations289

Citations

Mentioned in this Paper

Genome
RNA, Untranslated
Transcription, Genetic
Protein Biosynthesis
Retinal Nonattachment, Nonsyndromic Congenital
RNA Processing, Post-Transcriptional
Genome, Human
Evolution, Molecular
RNA
Cytology

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