The evaluation of oxidative stress in osteoarthritis

Medicine and Pharmacy Reports
Oana-Maria ZahanDaniela Fodor

Abstract

Osteoarthritis (OA) is a whole joint disease driven by abnormal biomechanics and attendant cell-derived and tissue-derived factors. The disease is multifactorial and polygenic, and its progression is significantly related to oxidative stress and reactive oxygen species (ROS). Augmented ROS generation can cause the damage of structural biomolecules of the joint and, by acting as intracellular signaling component, ROS are associated with various inflammatory responses. By activating several signaling pathways, ROS have a vital importance in the patho-physiology of OA. This review is focused on the mechanism of ROS which regulate intracellular signaling processes, chondrocyte senescence and apoptosis, extracellular matrix synthesis and degradation, along with synovial inflammation and dysfunction of the subcondral bone, targeting the complex oxidative stress signaling pathways.

Citations

Feb 11, 2021·Pharmaceuticals·Oliver McClurgLinda Troeberg
Apr 4, 2021·International Journal of Molecular Sciences·Sara CheleschiAntonella Fioravanti
Jun 3, 2021·International Journal of Molecular Sciences·Alessandro de SireAntonio Ammendolia
Jul 3, 2021·Antioxidants·Nicoleta Bianca TudorachiElena Mihaela Cărăuşu
May 1, 2021·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Zubeyir ElmazogluÇimen Karasu

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Methods Mentioned

BETA
deamination

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