The evaluation of serum levels of testosterone in type 2 diabetic men and its relation with lipid profile

Journal of Clinical and Diagnostic Research : JCDR
Nirmali MattackDibyaratna Patgiri

Abstract

Type 2 diabetes mellitus (T2DM) is the predominant form of diabetes worldwide and much is known about its patho-physiology. Yet, newer aspects related to it are being constantly explored. For ages, testosterone has been known to men as the male sex hormone but now it has been shown by certain studies that it might have a role in the development of metabolic disorders like type 2 diabetes. This study was carried out to determine the relation of testosterone levels with type 2 diabetes mellitus and lipid profile in North East Indian men aged 31 to 73 years. This case control study comprised of 40 type 2 diabetic men and 40 age matched non diabetic healthy men. Testosterone, SHBG levels and lipid profile were evaluated in both the groups along with anthropometric measurements and were statistically analysed. Serum total and free testosterone and Sex Hormone Binding Globulin were significantly lower in the test group than in the control group. Prevalence of type 2diabetes was five times higher in men having a total testosterone less than 8nmol/L and 5.57 times higher in those having a free testosterone of less than 0.225nmol/L. Fasting blood glucose showed a strong negative correlation with total and free testosterone. Glycated hae...Continue Reading

Citations

Jun 6, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Brigitte WexSoha N Yazbek
Jul 19, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Mari Carmen Bernal-SorianoLucy A Parker

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