The evaluation of the impact of titania nanotube covers morphology and crystal phase on their biological properties

Journal of Materials Science. Materials in Medicine
Żaneta LewandowskaBeata Sadowska

Abstract

The highly ordered titanium dioxide nanotube coatings were produced under various electrochemical conditions on the surface of titanium foil. The anodization voltage changes proved to be a main factor which directly affects the nanotube morphology, structure, and wettability. Moreover we have noticed a significant dependence between the size and crystallinity of TiO2 layers and the adhesion/proliferation of fibroblasts and antimicrobial properties. Cellular functionality were investigated for up to 3 days in culture using a cell viability assay and scanning electron microscopy. In general, results of our studies revealed that fibroblasts adhesion, proliferation, and differentiation on the titania nanotube coatings is clearly higher than on the surface of the pure titanium foil. The formation of crystallic islands in the nanotubes structure induced a significant acceleration in the growth rate of fibroblasts cells by as much as ~200 %. Additionally, some types of TiO2 layers revealed the ability to the reduce of the staphylococcal aggregates/biofilm formation. The nanotube coatings formed during the anodization process using the voltage 4 V proved to be the stronger S. aureus aggregates/biofilm inhibitor in comparison to the unc...Continue Reading

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Citations

Dec 14, 2018·International Journal of Molecular Sciences·Aleksandra RadtkePiotr Piszczek
Jan 30, 2020·Journal of Clinical Medicine·Piotr PiszczekWaldemar Jedrzejczyk
Nov 29, 2016·Expert Opinion on Drug Delivery·Karan Gulati, Sašo Ivanovski
Oct 26, 2021·Frontiers in Cellular and Infection Microbiology·Jagjit Singh DhaliwalRubens Ferreira Albuquerque Junior

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Methods Mentioned

BETA
transmission electron microscopy
ELISA
scanning electron microscopy

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