Aug 22, 2007

The evaluation of the neuroprotective effects of bispyridinium oximes in tabun-poisoned rats

Journal of Toxicology and Environmental Health. Part a
Jiri Kassa, Jana Zdarova Karasova

Abstract

Tabun (O-ethyl-N,N-dimethyl phosphoramidocyanidate) belongs to the group of highly toxic organophosphorus compounds that may be used as chemical warfare agents for military as well as terrorist purposes. Tabun differs from other highly toxic organophosphates by the fact that commonly used antidotes are not able adequately to prevent tabun-induced acute toxic effects. The neuroprotective effects of four bispyridinium oximes (K075, trimedoxime, HI-6, obidoxime) in combination with atropine on rats poisoned with tabun at a sublethal dose (150 microg/kg i.m.; 80% of LD50 value) were studied. Tabun-induced neurotoxicity was monitored using a functional observational battery and automatic measurement of motor activity at 24 h and 7 d following tabun challenge. The results indicated that all tested oximes combined with atropine enabled tabun-poisoned rats to survive 7 d following challenge. Trimedoxime combined with atropine was the most effective antidote in decreasing tabun-induced neurotoxicity in the case of sublethal poisonings among all oximes tested. Due to its neuroprotective effects, trimedoxime may be considered to be more suitable oxime for the antidotal treatment of acute tabun exposure than currently used oximes (obidoxim...Continue Reading

Mentioned in this Paper

Molecular Motor Activity
Organophosphorus Poisoning
Oximes
Atropine
Cholinesterase Inhibitors, Reversible
Atropinum, atropine
Polychemotherapy
Observation - Diagnostic Procedure
Atropen
Obidoxime

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