PMID: 7515773Apr 1, 1994Paper

The evaluation of the oximetric and Doppler sonographic parameters in patients with chronic venous insufficiency. A controlled double-blind clinical study versus placebo

La Clinica terapeutica
F Binaghi, P F Fronteddu

Abstract

Twenty four patients suffering from chronic venous insufficiency of the lower limbs were treated with sulfo-mucopolysaccharides (SMPS) or placebo in a double-blind controlled study. At recruitment, and again at 60 and 120 days of ongoing treatment, each patient was tested for transcutaneous partial oxygen tension and for pressure in the posterior tibial vein and saphena by Doppler sonography. Findings were assessed in each case separately for the affected limb versus the unaffected, or for the more severely affected versus the contralateral limb in patients affected bilaterally. Patients treated with the test product, but not those treated with placebo, showed definite reduction of venous pressure in the posterior tibial vein and internal saphena of the affected or more severely affected limb at 60 days of treatment: namely -35% from basal for the posterior tibial vein and -28% for the internal saphena. Again on the affected or more severely affected side, patients treated with SMPS showed improved transcutaneous oxygen tension amounting to +13.8% from basal at 60 days, as opposed to worsening condition in the placebo group.

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