The Ever-Growing Puzzle of Asynchronous Release

Frontiers in Cellular Neuroscience
Andrei RozovFliza Valiullina-Rakhmatullina

Abstract

Invasion of an action potential (AP) to presynaptic terminals triggers calcium dependent vesicle fusion in a relatively short time window, about a millisecond, after the onset of the AP. This allows fast and precise information transfer from neuron to neuron by means of synaptic transmission and phasic mediator release. However, at some synapses a single AP or a short burst of APs can generate delayed or asynchronous synaptic release lasting for tens or hundreds of milliseconds. Understanding the mechanisms underlying asynchronous release (AR) is important, since AR can better recruit extrasynaptic metabotropic receptors and maintain a high level of neurotransmitter in the extracellular space for a substantially longer period of time after presynaptic activity. Over the last decade substantial work has been done to identify the presynaptic calcium sensor that may be involved in AR. Several models have been suggested which may explain the long lasting presynaptic calcium elevation a prerequisite for prolonged delayed release. However, the presynaptic mechanisms underlying asynchronous vesicle release are still not well understood. In this review article, we provide an overview of the current state of knowledge on the molecular c...Continue Reading

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Citations

May 8, 2020·Journal of Neurochemistry·Katherine BonnycastleMichael A Cousin
Jun 18, 2020·Frontiers in Immunology·Marwa SleimanJens Rettig
Feb 24, 2021·Cellular and Molecular Life Sciences : CMLS·Mónica C Quiñones-Frías, J Troy Littleton
May 2, 2021·Science Advances·Daniela IvanovaMichael A Cousin
Jan 1, 2022·ELife·Bin Wang, Olga K Dudko

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