The EVI1 gene in myeloid leukemia

Leukemia
Giuseppina Nucifora

Abstract

Leukemia is an acquired genetic disease caused by the accumulation of chromosomal abnormalities which modify either the biochemical property or the level of expression of proteins. Frequent genetic abnormalities identified in human leukemia are chromosomal rearrangements such as chromosomal translocations and inversions. Chromosome band 3q26 is the site of the breakpoint of recurring translocations and inversions observed in patients with myeloid leukemias. Two genes located at 3q26 have been implicated in development or progression of myeloid leukemia. They are MDS1 and EVI1. MDS1, first identified as part of a fusion transcript resulting from the t(3;21)(q26;q22), encodes a small protein of unknown function. EVI1 encodes a zinc finger protein inappropriately overexpressed by chromosomal rearrangements (in man) or by retroviral insertion (in the mouse). Both genes are rearranged by the t(3;21)(q26;q22) and by the t(3;12)(p13;q22). As a result of the translocation, they are expressed as fusion genes either with AML1 or with TEL. EVI1 and MDS1 are unusual in that they can either encode separate proteins, or they can be expressed as one protein which we named MDS1/EVI1. EVI1 and MDS1/EVI1 have opposite functions as transcription ...Continue Reading

Citations

Nov 14, 2000·The Prostate·H P SattlerB Wullich
Jan 5, 2010·International Journal of Hematology·Akira Hangaishi, Mineo Kurokawa
Sep 16, 2003·Blood Cells, Molecules & Diseases·Silvia BuonamiciGiuseppina Nucifora
Jan 21, 2000·The International Journal of Biochemistry & Cell Biology·H Hirai
Nov 1, 2003·Best Practice & Research. Clinical Haematology·Francesco Lo-CocoWilson H Miller
Dec 13, 2005·Nature Clinical Practice. Oncology·Pierre Fenaux
Feb 13, 2001·British Journal of Haematology·S E LangabeerUNKNOWN MRC Adult Leukaemia Working Party
Dec 11, 2002·British Journal of Haematology·Osamu SasakiTakeshi Sasaki
Jun 13, 2002·Reviews in Clinical and Experimental Hematology·Cristina MecucciRoberta La Starza
Jan 10, 2001·Current Opinion in Oncology·R Wieser
Dec 17, 2003·Current Opinion in Hematology·Ruibao Ren
Dec 23, 2010·Future Oncology·Etienne De BraekeleerMarc De Braekeleer
Jan 11, 2014·Current Hematologic Malignancy Reports·Paolo Neviani
Aug 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Daniel HelblingThomas Pabst
Jan 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Vijay P S RawatChristian Buske
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·G M CuencoR Ren
Jan 9, 2014·Leukemia & Lymphoma·Xiangdong XuHuan-You Wang
Mar 20, 2003·Cancer Investigation·Joäelle MichaudRobert Escher
Jun 12, 2012·Cancer Genetics·Beata GrygalewiczBarbara Pieńkowska-Grela
Jan 31, 2007·Annals of the New York Academy of Sciences·Daniela CilloniGiuseppe Saglio
Nov 15, 2007·Cancer·Wolfgang KernSusanne Schnittger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.