Oct 30, 2016

The evidence for microbiome manipulation in inflammatory arthritis

Rheumatology
Hannah Jethwa, Sonya Abraham

Abstract

The human body consists of millions of commensal bacteria (the microbiome), with the intestinal tract being the most prevalent site of colonization. This colonization process begins at birth, and despite numerous factors such as ageing, diet and drug use affecting the microbiome make-up, by adulthood the composition of the gut bacteria is relatively consistent across local populations. The recent advent of new scientific techniques has enabled us to explore how the microbiome affects health and, in particular, has shed light on the involvement of the microbiome in the pathogenesis of inflammatory disease. In this review we highlight the current evidence for microbiome manipulation in inflammatory arthritis in animal and human models and discuss potential therapeutics targeting the microbiome as treatment for these diseases.

  • References41
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References

  • References41
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Citations

Mentioned in this Paper

Pathogenic Aspects
Diet
Pathogenesis
Bacteriocidal Agents
Inflammatory Disorder
Rheumatoid Arthritis
Entire Intestinal Tract
Pharmacologic Substance
Microbiome
Arthritis

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