PMID: 1203876Dec 1, 1975Paper

The evolution of cancer of the colon and rectum

Cancer
T MutoB C Morson

Abstract

The malignant potential of adenomas of the colon and rectum varies with size, histological type and grade of epithelial atypia. The adenomatous polyp is usually small and has a low malignant potential, whereas tumors with a villous structure are usually larger and have a much higher cancer rate. Severe atypia is more common in villous adenomas than in adenomatous polyps. Evidence is presented which suggests that most cancers of the colon and rectum have evolved through the polyp-cancer sequence although the majority of adenomas do not becoma cancerous during a normal adult life span. The slow evolution of the polyp-cancer sequence is stressed. The implications of the polyp-cancer sequence for the design of cancer prevention programmes and the study of the aetiology of large bowel cancer are discussed.

References

Jan 1, 1975·Diseases of the Colon and Rectum·R J Heald, H J Bussey
May 1, 1975·The British Journal of Surgery·B Leppard, H J Bussey
Jan 16, 1971·Lancet·M J HillR E Williams
Mar 1, 1967·Diseases of the Colon and Rectum·T C LescherO H Beahrs
Jan 1, 1973·Journal of Clinical Pathology·T MutoB C Morson
Dec 1, 1972·The American Journal of Clinical Nutrition·B S Drasar, M J Hill
Jan 1, 1974·Current Problems in Surgery·W I Wolff, H Shinya
Feb 24, 1973·British Medical Journal·C WilliamsK R Rutter
Apr 1, 1973·American Journal of Clinical Pathology·R E Fechner
Sep 1, 1973·Diseases of the Colon and Rectum·W Haenszel, P Correa
Feb 1, 1970·Current Problems in Surgery·B C Morson, H J Bussey
May 1, 1971·Diseases of the Colon and Rectum
Jan 15, 1972·International Journal of Cancer. Journal International Du Cancer·P CorreaW Haenszel
Jul 1, 1971·Cancer·C E Welch
Jun 1, 1971·Gut·F Potet, J Soullard
Jan 1, 1970·American Journal of Clinical Pathology·C H Fung, H Goldman
Sep 1, 1970·Diseases of the Colon and Rectum·T R SmithI S Kaplowitz
Nov 1, 1970·Cancer·C G Bremner, L V Ackerman
Nov 1, 1968·Journal of Clinical Pathology·J F Arthur
May 1, 1969·Gut·V AriesR E Williams
Mar 1, 1966·Journal of Medical Genetics·A M VealeB C Morson
Oct 1, 1967·Cancer·H T Enterline, D A Arvan
Oct 1, 1958·Annals of Surgery·J S SPRATTC A MOYER
Sep 1, 1959·Archives of Surgery·J W COLE, W D HOLDEN
Sep 6, 1962·The New England Journal of Medicine·B CASTLEMAN, H I KRICKSTEIN
Feb 3, 1962·JAMA : the Journal of the American Medical Association·H T ENTERLINEW T FITTS
Jul 1, 1960·Diseases of the Colon and Rectum·R A SCARBOROUGH

❮ Previous
Next ❯

Citations

Jul 24, 2004·Critical Reviews in Clinical Laboratory Sciences·Stephan E BaldusFranz-Georg Hanisch
Jan 1, 1988·Scandinavian Journal of Gastroenterology. Supplement·J MosvoldA Serck-Hanssen
Jun 28, 2008·Scandinavian Journal of Gastroenterology·Soo Young ParkWon Ho Kim
Jul 9, 2008·Scandinavian Journal of Gastroenterology·Sang Kil LeeNam Kyu Kim
Dec 1, 1987·Scandinavian Journal of Gastroenterology·B BørkjeO D Laerum
Sep 14, 2007·Scandinavian Journal of Gastroenterology·Yutaka YamajiMasao Omata
Dec 28, 2006·Scandinavian Journal of Gastroenterology·Sanna A MulderErnst J Kuipers
Jul 28, 1999·Scandinavian Journal of Gastroenterology·C A RubioE Jaramillo
Oct 1, 1993·Scandinavian Journal of Gastroenterology·O D JørgensenC Fenger
Sep 23, 1997·Scandinavian Journal of Gastroenterology·P NetzerA Schmassmann
Nov 15, 1997·Scandinavian Journal of Gastroenterology·G NuskoE G Hahn
Sep 1, 1989·Scandinavian Journal of Gastroenterology·L G JohannsenN O Jacobsen
Jan 11, 2012·Scandinavian Journal of Gastroenterology·Anouar TeriakyNilesh Chande
Apr 1, 1995·Scandinavian Journal of Gastroenterology·M RisioF P Rossini
Jan 1, 1996·Scandinavian Journal of Gastroenterology. Supplement·T D Bolin
Jul 24, 2004·Expert Review of Anticancer Therapy·David BurlingSteve Halligan
Jan 1, 1993·Acta Oncologica·T HatadaJ Utsunomiya
Jun 28, 2016·Seminars in Ultrasound, CT, and MR·Lorna Woodbridge, Peter Wylie
Dec 29, 2015·Cancer Letters·Cecilia WilliamsJan-Åke Gustafsson
Mar 25, 2016·The Indian Journal of Surgery·Ali AktekinGul Babacan Abanonu
Jun 1, 1994·European Journal of Biochemistry·F VavasseurI Brockhausen
Feb 9, 2012·International Journal of Surgical Oncology·D SpeakeR F T McMahon
Sep 30, 1995·Annals of the New York Academy of Sciences·S J Winawer
Feb 5, 2013·Gastrointestinal Endoscopy·Susan G Coe, Michael B Wallace
May 19, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Edith LahnerBruno Annibale
Nov 2, 2015·Mayo Clinic Proceedings·Diana G RedwoodDavid A Ahlquist
Nov 30, 2011·Best Practice & Research. Clinical Gastroenterology·Christina M Laukaitis, Eugene W Gerner
Jan 1, 1981·Experimental Pathology·M Balázs, A Kovács

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.