The evolution of compositionally and functionally distinct actin filaments

Journal of Cell Science
Peter GunningRobert C Robinson

Abstract

The actin filament is astonishingly well conserved across a diverse set of eukaryotic species. It has essentially remained unchanged in the billion years that separate yeast, Arabidopsis and man. In contrast, bacterial actin-like proteins have diverged to the extreme, and many of them are not readily identified from sequence-based homology searches. Here, we present phylogenetic analyses that point to an evolutionary drive to diversify actin filament composition across kingdoms. Bacteria use a one-filament-one-function system to create distinct filament systems within a single cell. In contrast, eukaryotic actin is a universal force provider in a wide range of processes. In plants, there has been an expansion of the number of closely related actin genes, whereas in fungi and metazoa diversification in tropomyosins has increased the compositional variety in actin filament systems. Both mechanisms dictate the subset of actin-binding proteins that interact with each filament type, leading to specialization in function. In this Hypothesis, we thus propose that different mechanisms were selected in bacteria, plants and metazoa, which achieved actin filament compositional variation leading to the expansion of their functional diversity.

References

Mar 29, 1979·Nature·G N PhillipsC Cohen
Nov 5, 1992·Nature·M K BalasubramanianS M Hemmingsen
Dec 1, 1988·Molecular and Cellular Biology·V MagdolenW Bandlow
Feb 17, 1968·Nature·M Kimura
Nov 15, 1984·Nature·T Mitchison, M Kirschner
Jun 1, 1982·The Journal of Cell Biology·J D Pardee, J A Spudich
Jun 15, 1994·Biochemical and Biophysical Research Communications·L A Sung, J J Lin
Oct 28, 1993·Nature·C E SchuttU Lindberg
Jul 1, 1996·The Plant Journal : for Cell and Molecular Biology·Y Q AnR B Meagher
Dec 1, 1996·Journal of Bacteriology·S G Addinall, J Lutkenhaus
Jan 1, 1997·Annual Review of Cell and Developmental Biology·A Desai, T J Mitchison
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·D C WinterR Li
Aug 15, 2000·Annual Review of Biophysics and Biomolecular Structure·T D PollardR D Mullins
Nov 10, 2000·Science·M Lynch, J S Conery
Jan 9, 2001·Nature Cell Biology·T WittmannA Desai
Aug 18, 2001·Current Biology : CB·N Tang, E M Ostap
Sep 7, 2001·Nature·F van den EntJ Löwe
Nov 27, 2001·Science·R C RobinsonT D Pollard
Dec 12, 2001·Nature Cell Biology·Marie EvangelistaAanthony Bretscher
May 16, 2002·Histopathology·P G Chu, L M Weiss
Mar 13, 2003·Molecular Biology of the Cell·Nicole S BryceRon P Weinberger
May 3, 2003·Current Opinion in Structural Biology·Edward H Egelman
Dec 9, 2003·The Journal of Biological Chemistry·Alla S Kostyukova, Sarah E Hitchcock-DeGregori
Mar 3, 2004·Molecular and Cellular Biology·J HookP Gunning
Mar 23, 2004·Nucleic Acids Research·Robert C Edgar
Jun 20, 2006·Trends in Biochemical Sciences·M Bishr OmaryJian Liao
Sep 9, 2006·Microbiology and Molecular Biology Reviews : MMBR·James B Moseley, Bruce L Goode
Jan 16, 2008·Physiological Reviews·Peter GunningEdna Hardeman
Jul 16, 2008·The Journal of Cell Biology·Ville O PaavilainenPekka Lappalainen
Nov 28, 2008·Nucleic Acids Research·Derek WilsonJulian Gough
Jan 20, 2009·Bioinformatics·Andrew M WaterhouseGeoffrey J Barton
Jan 23, 2009·Nature·Toshiro OdaAkihiro Narita
Mar 13, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michele A JaegerJames M Ervasti

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Citations

Feb 6, 2016·Scientific Reports·Nikolas HundtDietmar J Manstein
Feb 14, 2016·Proceedings of the National Academy of Sciences of the United States of America·Shimin JiangRobert C Robinson
Sep 2, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·James McInerneyMary J O'Connell
Jul 17, 2015·Proceedings of the National Academy of Sciences of the United States of America·Umesh GhoshdastiderRobert C Robinson
Apr 20, 2016·Archives of Biochemistry and Biophysics·Mert ColpanAlla S Kostyukova
Jul 12, 2016·Veterinary Parasitology·Rosa Ma Bermúdez-CruzM Guadalupe Ortega-Pierres
Apr 10, 2016·Traffic·Dietmar J Manstein, Daniel P Mulvihill
Jul 9, 2016·Protein Science : a Publication of the Protein Society·Julien R C BergeronJustin M Kollman
Sep 8, 2016·The Journal of Physical Chemistry. B·Yaw AwuniYuguang Mu
Oct 27, 2016·Cytoskeleton·Philip R NicovichTill Böcking
Jun 20, 2017·The Journal of Investigative Dermatology·Rudolf Happle
Oct 27, 2017·International Journal of Molecular Sciences·Jianfang HuangCaihuan Ke
Oct 2, 2017·Cell Biology and Toxicology·Mina HwangSeong-Ho Koh
Dec 20, 2017·Journal of Integrative Neuroscience·J Shashi Kiran Reddy, Contzen Pereira
Dec 18, 2018·PLoS Neglected Tropical Diseases·So Myung SongHak Sun Yu
Jan 13, 2019·Allergy·Peggy Ozias-Akins, Heimo Breiteneder
Mar 17, 2018·Scientific Reports·Anthony J KeeEdna C Hardeman
Mar 29, 2019·JCI Insight·Maarten M SteinzJohanna T Lanner
Jan 4, 2017·Communicative & Integrative Biology·Shimin JiangRobert C Robinson

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