The evolution of gene expression, structure and function of transthyretin

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
G Schreiber, S J Richardson

Abstract

Thyroxine, the most abundant thyroid hormone in blood, partitions into lipid membranes. In a network-like system, thyroxine-binding plasma proteins counteract this partitioning and establish intravascular, protein-bound thyroxine pools. These are far larger than the free thyroxine pools. In larger eutherians, proteins specifically binding thyroxine are albumin, transthyretin, and thyroxine-binding globulin. Some binding of thyroxine can also occur to lipoproteins. During evolution, transthyretin synthesis first appeared in the choroid plexus of the stem reptiles, about 300 million years ago. Transthretin synthesis in the liver evolved much later, independently, in birds, eutherians and some marsupial species. Analysis of 57 human transthyretin variants suggests that most mutations in transthyretin are not compatible with its normal metabolism and lead to its deposition as amyloid. Analysis of transthyretin or its gene in 20 different species shows that evolutionary changes of transthyretin predominantly occurred near the N-termini. A change in RNA splicing between exon 1 and exon 2 led to a decrease in hydrophobicity and length of the N-termini. It is proposed that the selection pressure producing these changes was the need for...Continue Reading

References

Jan 1, 1977·Annual Review of Biochemistry·A C WilsonT J White
Nov 1, 1979·Scientific American·M Kimura
Dec 1, 1992·Internal Medicine·M NakazatoS Matsukura
Oct 1, 1992·Journal of the Neurological Sciences·N TakahashiS Tarui
Jul 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A FerliniA Forabosco
Jul 1, 1992·Clinical Genetics·I L AlvesM J Saraiva
Jan 1, 1992·Thyroid : Official Journal of the American Thyroid Association·B J ScrimshawP M George
Dec 1, 1992·Journal of Medical Genetics·T UemichiM D Benson
Jan 1, 1992·Cytogenetics and Cell Genetics·H QiuZ Cheng
Aug 31, 1992·Biochemical and Biophysical Research Communications·T MurakamiM Ando
Aug 31, 1992·Biochemical and Biophysical Research Communications·H NishiT Sasazuki
Mar 12, 1992·Nature·M J Novacek
Mar 1, 1992·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·W Duan, G Schreiber
Dec 1, 1991·Brain : a Journal of Neurology·H StauntonA E Harding
Oct 21, 1991·Biochimica Et Biophysica Acta·M R AlmeidaM J Saraiva
Jan 31, 1992·Biochemical and Biophysical Research Communications·T MurakamiS Araki
Nov 1, 1991·Basic Research in Cardiology·M R AlmeidaM J Saraiva
Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·P J HarmsG Schreiber
Oct 1, 1990·The Journal of Steroid Biochemistry and Molecular Biology·C M MendelJ T Murai
Nov 13, 1987·Biochemical and Biophysical Research Communications·L SavuE A Nunez

❮ Previous
Next ❯

Citations

Nov 8, 2008·Development Genes and Evolution·Mathilde ParisVincent Laudet
Feb 13, 2003·Molecular and Cellular Endocrinology·Akinori IshiharaKiyoshi Yamauchi
Jul 20, 1999·Molecular and Cellular Endocrinology·J Köhrle
Apr 8, 1998·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·S J RichardsonG Schreiber
Jun 5, 2003·Biochimica Et Biophysica Acta·Gwendolyn Barceló-CoblijnTibor Farkas
Dec 12, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·D M PowerG E Sweeney
Jan 18, 2003·Vascular Pharmacology·Hartwig Wolburg, Andrea Lippoldt
Jan 25, 2003·European Journal of Biochemistry·Therese EneqvistA Elisabeth Sauer-Eriksson
Jan 23, 1999·European Journal of Biochemistry·L ChangG Schreiber
Nov 27, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Francisco Ucán-MarínRobert J Letcher
Oct 25, 2012·American Journal of Physiology. Endocrinology and Metabolism·Julie A MonkSamantha J Richardson
Jan 30, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Cecilia R A SantosDeborah M Power
Oct 6, 2000·General and Comparative Endocrinology·D M PowerC R Santos
Oct 6, 2000·General and Comparative Endocrinology·K YamauchiS J Richardson
Sep 12, 2001·General and Comparative Endocrinology·M SammarE Lubzens
Feb 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·László G PuskásTibor Farkas
Feb 5, 2002·General and Comparative Endocrinology·Samantha J RichardsonGerhard Schreiber
Aug 1, 2009·Cellular and Molecular Life Sciences : CMLS·Joel N Buxbaum, Natàlia Reixach
Jul 22, 2015·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Younhee ChoJeffery W Kelly
Sep 18, 2007·The American Journal of the Medical Sciences·Amir Said Alizadeh NaderiPeter Igarashi
Dec 15, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Kiyoshi Yamauchi, Gobun Sai
Jul 16, 2008·Molecular and Cellular Endocrinology·Isabel MorgadoDeborah M Power
Feb 5, 2008·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Ryoji EguchiKiyoshi Yamauchi
Jan 16, 2007·General and Comparative Endocrinology·Richard G ManzonLori A Manzon
Nov 2, 2006·Journal of Neurochemistry·Xu HouDavid H Small
Jul 1, 2008·Proteomics. Clinical Applications·Urban A KiernanRandall W Nelson
Sep 4, 2009·The FEBS Journal·Samantha J Richardson
Jun 20, 2006·Proteins·Sarah C HennebrySamantha J Richardson
Oct 15, 2014·Journal of Cellular and Molecular Medicine·Andrea HenzeAysel Ozpinar
Aug 15, 2000·Journal of Structural Biology·R Kisilevsky

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.