The evolution of genetic diversity

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
B C Clarke

Abstract

The existence within natural populations of large amounts of genetic variation in molecules and morphology presents an evolutionary problem. The 'neutralist' solution to this problem, that the variation is usually unimportant to the organism displaying it, has now lost much of its strength. Interpretations that assume widespread heterozygous advantage also face serious difficulties. A resolution is possible in terms of frequency-dependent selection by predators, parasites and competitors. The evidence for pervasive frequency-dependent selection is now very strong. It appears to follow naturally from the behaviour of predators, from the evolutionary lability of parasites, from the ecology of competition and, at the molecular level, from the phenomena of enzyme kinetics. Such selection can explain the maintenance not only of conventional polymorphism but also of continuous variation in both molecular and morphological characters. It can account for the occurrence of diversity within groups of haploid and self-fertilizing organisms, and for the evolution of differences between individuals in their systems of genetic control.

References

Oct 15, 1985·Experientia·H J Bremermann
Jul 1, 1993·International Journal for Parasitology·G D Gray, H S Gill
Jan 1, 1983·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·A BauermeisterI A Nimmo
Feb 1, 1980·Genetical Research·J M Smith, R Hoekstra
Aug 4, 2004·Proceedings of the National Academy of Sciences of the United States of America·David J Earl, Michael W Deem
Nov 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Andrew R Weeks, Ary A Hoffmann
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J W Curtsinger
Apr 24, 2010·Science·Michael Doebeli, Iaroslav Ispolatov
Jan 1, 1996·Annual Review of Phytopathology·K Clay, P X Kover
Oct 9, 2008·BMC Evolutionary Biology·Darren J ObbardTom J Little
Jul 29, 2004·Genetics·Reinhard Bürger, Alexander Gimelfarb
Nov 28, 2014·Proceedings. Biological Sciences·Pedro GómezAngus Buckling
Mar 17, 2009·Theoretical Population Biology·Carlo Matessi, Kristan A Schneider
Aug 30, 2008·Theoretical Population Biology·Kristan A Schneider
Jan 8, 2008·Journal of Theoretical Biology·Stephan Peischl, Reinhard Bürger
Sep 2, 2005·Journal of Evolutionary Biology·T J M Van Dooren
May 29, 2009·Evolution; International Journal of Organic Evolution·Britt Koskella, Curtis M Lively
Aug 24, 2007·Journal of Evolutionary Biology·Angus Buckling, D J Hodgson
Nov 28, 2007·Evolution; International Journal of Organic Evolution·Rebecca BenmayorDavid J Hodgson
Sep 3, 2011·Evolution; International Journal of Organic Evolution·Emanuel A FronhoferHans-Joachim Poethke
Sep 29, 2009·Evolution; International Journal of Organic Evolution·Stephan Peischl, Kristan A Schneider
Aug 26, 2014·Journal of Evolutionary Biology·C A McLeanA Moussalli
Mar 19, 2014·Evolution; International Journal of Organic Evolution·Kristina Karlsson GreenBengt Hansson
Aug 21, 2013·The New Phytologist·Lynda F Delph, John K Kelly
Apr 1, 2015·Evolution; International Journal of Organic Evolution·L Ruth RivkinChristina M Caruso
Nov 13, 2008·Current Biology : CB·Karin Kiontke
Jun 15, 1999·Theoretical Population Biology·J MolofskyS Levin
Oct 12, 2018·Molecular Ecology·Pawel SierocinskiAngus Buckling
Feb 22, 1992·Proceedings. Biological Sciences·A G DaviesJ A McKenzie
Jul 22, 1991·Proceedings. Biological Sciences·D J Lipman, W J Wilbur
Aug 21, 1987·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J K BowmakerJ D Mollon
Sep 22, 1984·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J D MollonG H Jacobs
Apr 24, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·B C ReganJ D Mollon
Aug 22, 1995·Proceedings. Biological Sciences·S Gavrilets, A Hastings

Related Concepts

Gene Polymorphism
Host-Parasite Interactions
Science of Morphology
Drosophila
Haploid Cell
Bionomics
Organism
Alleles
Genetic Polymorphism
Drosophila melanogaster

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.