The evolution of GRADE (part 2): Still searching for a theoretical and/or empirical basis for the GRADE framework

Journal of Evaluation in Clinical Practice
Mathew Mercuri, Amiram Gafni

Abstract

The GRADE framework has been widely adopted as the preferred method for developing clinical practice recommendations. In the first article of our three part series examining the evolution of GRADE, we showed an absence (in the first two versions of GRADE) of a theoretical basis and/or empirical data to support why the presented criteria for determining the quality of evidence regarding the effect estimate and the components under consideration for determining the strength of the recommendation were included and other criteria/components excluded. Furthermore, often, it was not clear how to operationalize the included criteria/components (and integrate them) when using the framework. In part 2 of this series, we examine if version 3 of GRADE offered improvements on previous versions with respect to a justification scheme and how to operationalize the framework's criteria/components. Narrative review. Our examination suggests that version 3 has done little to improve on the justification scheme that sustains GRADE. Still absent is a justification (theoretical and/or empirical) for why the criteria/components were chosen. Likewise, version 3 is still lacking clarity regarding how to implement and integrate the criteria/considerati...Continue Reading

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Jul 17, 2018·Journal of Evaluation in Clinical Practice·Mathew Mercuri, Amiram Gafni

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Citations

Aug 2, 2018·Journal of Evaluation in Clinical Practice·Mathew Mercuri, Amiram Gafni
Aug 31, 2018·Journal of Evaluation in Clinical Practice·Michael LoughlinStephen Buetow
Feb 23, 2019·Journal of Evaluation in Clinical Practice·Sasha Lawson-Frost
Sep 10, 2020·Thyroid : Official Journal of the American Thyroid Association·Anna M SawkaJacqueline Jonklaas
Sep 18, 2020·Journal of Evaluation in Clinical Practice·Brian Baigrie, Mathew Mercuri
Feb 1, 2020·Current Pain and Headache Reports·Laxmaiah ManchikantiJoshua A Hirsch
Nov 27, 2020·Journal of Evaluation in Clinical Practice·Robert Mugerauer
Feb 14, 2021·Journal of Evaluation in Clinical Practice·Lucie Perillat, Brian S Baigrie

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