The evolution of H5N1 influenza viruses in ducks in southern China

Proceedings of the National Academy of Sciences of the United States of America
H ChenK Yu

Abstract

The pathogenicity of avian H5N1 influenza viruses to mammals has been evolving since the mid-1980s. Here, we demonstrate that H5N1 influenza viruses, isolated from apparently healthy domestic ducks in mainland China from 1999 through 2002, were becoming progressively more pathogenic for mammals, and we present a hypothesis explaining the mechanism of this evolutionary direction. Twenty-one viruses isolated from apparently healthy ducks in southern China from 1999 through 2002 were confirmed to be H5N1 subtype influenza A viruses. These isolates are antigenically similar to A/Goose/Guangdong/1/96 (H5N1) virus, which was the source of the 1997 Hong Kong "bird flu" hemagglutinin gene, and all are highly pathogenic in chickens. The viruses form four pathotypes on the basis of their replication and lethality in mice. There is a clear temporal pattern in the progressively increasing pathogenicity of these isolates in the mammalian model. Five of six H5N1 isolates tested replicated in inoculated ducks and were shed from trachea or cloaca, but none caused disease signs or death. Phylogenetic analysis of the full genome indicated that most of the viruses are reassortants containing the A/Goose/Guangdong/1/96-like hemagglutinin gene and ...Continue Reading

References

Mar 1, 1992·Microbiological Reviews·R G WebsterY Kawaoka
Sep 1, 1994·The Journal of General Virology·H KidaR G Webster
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y GuanR G Webster
Sep 18, 1999·Lancet·M PeirisK F Shortridge
Aug 23, 2000·Journal of Virology·R J WebbyR G Webster
Oct 24, 2000·Journal of Virology·J M KatzK Subbarao
Dec 29, 2000·Cellular and Molecular Life Sciences : CMLS·K Subbarao, J Katz
Dec 12, 2001·Journal of Virology·Robert G WebsterKennedy F Shortridge
May 22, 2002·Journal of Virology·Terrence M TumpeyDavid E Swayne
Jun 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Y GuanK F Shortridge
Aug 27, 2002·Nature Medicine·Sang Heui SeoRobert G Webster
May 2, 2003·Nature·Quirin Schiermeier
May 3, 2003·Lancet·Frank van Kolfschooten
Dec 4, 2003·Science·Richard J Webby, Robert G Webster
Apr 14, 2004·Journal of Virology·Katharine M Sturm-RamirezRobert G Webster

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Citations

Oct 1, 2010·Archives of Virology·J L WasilenkoM J Pantin-Jackwood
Mar 25, 2011·Archives of Virology·Ahmed S Abdel-MoneimAbdel-Aziz S Abu-Elsaad
Oct 12, 2012·Archives of Virology·Yanfeng YaoZe Chen
Feb 6, 2013·Archives of Virology·M K HassanJ Lubroth
May 16, 2009·Virus Genes·Jing-Jiao ZhouLi-Fang Jiang
Jun 6, 2013·Virus Research·Stephanie SonnbergRobert G Webster
Aug 7, 2013·Virus Research·Mary J Pantin-Jackwood, David L Suarez
Jul 2, 2010·Animal Health Research Reviews·Heather L Forrest, Robert G Webster
Nov 4, 2009·Cell Research·Gabriele NeumannYoshihiro Kawaoka
Aug 3, 2005·Nature Reviews. Microbiology·Taisuke Horimoto, Yoshihiro Kawaoka
Feb 18, 2005·The New England Journal of Medicine·Menno D de JongJeremy Farrar
Dec 3, 2004·The New England Journal of Medicine·Tran Tinh HienJeremy Farrar
Feb 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Chengjun LiYoshihiro Kawaoka
Nov 26, 2009·Avian Pathology : Journal of the W.V.P.A·Yinghua TangXiufan Liu
May 7, 2009·The Journal of Infectious Diseases·Lei ZhouHongjie Yu
Apr 28, 2005·Biosecurity and Bioterrorism : Biodefense Strategy, Practice, and Science·Stanley M Lemon, Adel A F Mahmoud
Jul 12, 2007·Bioinformatics·Xiu-Feng WanRuben Donis
Dec 18, 2008·Southern Medical Journal·Ioanna VasileiouAthanasios Giannopoulos
May 18, 2010·Journal of the Royal Society, Interface·L BourouibaM Wikelski
Mar 30, 2006·Antimicrobial Agents and Chemotherapy·Michael P MalakhovFang Fang
Apr 13, 2007·Clinical Microbiology Reviews·J S Malik PeirisYi Guan
Jul 28, 2010·Journal of Virology·Terri D StonerRobert G Webster

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