The evolution of heat shock protein sequences, cis-regulatory elements, and expression profiles in the eusocial Hymenoptera

BMC Evolutionary Biology
Andrew D NguyenSara Helms Cahan

Abstract

The eusocial Hymenoptera have radiated across a wide range of thermal environments, exposing them to significant physiological stressors. We reconstructed the evolutionary history of three families of Heat Shock Proteins (Hsp90, Hsp70, Hsp40), the primary molecular chaperones protecting against thermal damage, across 12 Hymenopteran species and four other insect orders. We also predicted and tested for thermal inducibility of eight Hsps from the presence of cis-regulatory heat shock elements (HSEs). We tested whether Hsp induction patterns in ants were associated with different thermal environments. We found evidence for duplications, losses, and cis-regulatory changes in two of the three gene families. One member of the Hsp90 gene family, hsp83, duplicated basally in the Hymenoptera, with shifts in HSE motifs in the novel copy. Both copies were retained in bees, but ants retained only the novel HSE copy. For Hsp70, Hymenoptera lack the primary heat-inducible orthologue from Drosophila melanogaster and instead induce the cognate form, hsc70-4, which also underwent an early duplication. Episodic diversifying selection was detected along the branch predating the duplication of hsc70-4 and continued along one of the paralogue bran...Continue Reading

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Citations

Feb 25, 2017·The Journal of Experimental Biology·Quentin WillotSerge Aron
Jun 30, 2018·Molecular Biology and Evolution·Laura M JonesPeter E Urwin
Nov 7, 2019·BMC Evolutionary Biology·Samuel N Bogan, Sean P Place
Feb 9, 2020·Biological Reviews of the Cambridge Philosophical Society·Daniel González-TokmanFabricio Villalobos
May 29, 2020·Evolution; International Journal of Organic Evolution·Mark J GarciaNicholas M Teets
Apr 26, 2017·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Andrew D NguyenSara Helms Cahan
Oct 7, 2020·Biological Reviews of the Cambridge Philosophical Society·Rémy Perez, Serge Aron
Feb 24, 2021·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Lukas SchraderJürgen Gadau
Nov 30, 2016·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Sara Helms CahanNicholas J Gotelli
Nov 4, 2017·The Journal of Experimental Biology·Brent L LockwoodKristi L Montooth
Apr 11, 2018·Environmental Science & Technology·Helen C PoyntonStephen Richards
Aug 21, 2021·Molecular Ecology·Rémy PerezSerge Aron

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Methods Mentioned

BETA
PCR
chip-seq

Software Mentioned

HMMER
FEL
Normfinder
MrBayes
MAFFT
MEME
MASS
WebLogos
HyPhy package
BLAST

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