The evolution of immunosuppression with FK506 in pediatric living-related liver transplantation

Transplantation
Y InomataT Hashida

Abstract

The effects of three FK506 induction regimens on pediatric living-related liver transplantation (LRLT) were studied retrospectively in terms of patient survival and adverse side effects. The patients consisted of 120 children, ranging from 3 to 210 months of age, who underwent a total of 122 LRLTs with a minimum follow-up of 6 months. Immunosuppression consisted of FK506 and low-dose steroids. FK506 was given in 3 ways: (1) high-dose intravenous (i.v.) induction, with FK506 begun at a dose of 0.15 mg/kg/day for the first 16 patients; (2) low-dose i.v. induction, with FK506 begun at a dose of 0.06 mg/kg/day for the next 45 patients; and (3) per os (p.o.) induction, with FK506 begun orally from the day prior to LRLT and continued postoperatively. Whole-blood trough levels of FK506 were monitored daily. Trough levels in the high induction group were often as high as 100 ng/ml compared with the level of 20 ng/ml in the p.o. induction group. Patient survivals were 75%, 89%, and 80% in the high-i.v. vs. low-i.v. vs. p.o. groups. The incidences of acute rejection were 12.5%, 22.2%, and 26.4%, and the incidences of viral infection were 56%, 38%, and 11% in the respective groups. Major adverse effects occurred with higher frequency in t...Continue Reading

References

Jul 1, 1991·Transplantation·Y YamaokaK Kumada
Oct 28, 1989·Lancet·T E StarzlA Jain
Oct 27, 1994·The New England Journal of Medicine·UNKNOWN U.S. Multicenter FK506 Liver Study Group
Jun 1, 1995·Clinical Transplantation·H C BodenheimerP Sheiner
Feb 1, 1993·Transplantation·S UemotoK Ozawa
May 1, 1994·Annals of Surgery·R W BusuttilS V McDiarmid

❮ Previous
Next ❯

Citations

Jul 2, 2005·European Journal of Clinical Pharmacology·Marie AntignacSaïk Urien
Dec 5, 1998·Transplantation Proceedings·P P LiuB Jawan
Jan 3, 2001·British Journal of Clinical Pharmacology·W J SamP C Ho
Dec 26, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Y SakamotoH Sato
Jan 27, 1998·Journal of Pediatric Gastroenterology and Nutrition·S V McDiarmid
Dec 10, 1997·Transplantation·E HatanoY Yamaoka
Aug 15, 2001·Transplantation·M TakatsukiK Tanaka
Jun 28, 2003·Transplantation·Mureo KasaharaKoichi Tanaka
Aug 2, 2007·Transplantation·Kaori KuramitsuShinji Uemoto
Jan 22, 2009·Transplantation·Elena Y YoshitoshiShinji Uemoto
Jun 6, 2009·Psychiatry and Clinical Neurosciences·Nien-Mu ChiuAndrew T A Cheng
Jul 13, 2004·Clinical Pharmacokinetics·Christine E Staatz, Susan E Tett
Nov 24, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·G V MazariegosJ Reyes
Dec 8, 1998·European Journal of Drug Metabolism and Pharmacokinetics·P E WallemacqN A Undre

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.