The evolution of intracellular responses to acrylamide in rat spinal ganglion neurons

Neuropathology and Applied Neurobiology
H B Jones, J B Cavanagh

Abstract

Acrylamide (30 mg or 50 mg/kg/day, 5 days each week) was injected intraperitoneally into rats for up to 4 weeks. Lumbar spinal ganglia, spinal cord and lumbrical muscle spindles were examined by light and electron microscopy at various times during this period. The first abnormalities in spinal ganglion neurons were seen at 7 days when an apparent increase in numbers of mitochondria, some being hypertrophic, were found in a few large light cells. This was 10 days before any significant Wallerian degeneration was found in muscle spindle sensory fibres. Mitochondrial changes became more marked with time and were later associated with RER disruption, loss of neurofilaments and peripheral displacement of the nucleus thus mimicking chromatolysis of the axon reaction. All these changes began, however, before axon degeneration. Evidence of increased satellite cell activity was maximal at 21 days. These changes are discussed in the light of the possibility that calcium entry into the cell may be seriously increased early in the intoxication as a direct result of the presence of acrylamide and that many of these cellular features are secondary responses to such an event. Distal degeneration of axons seems likely to be secondary to the p...Continue Reading

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Citations

Jan 1, 1986·Acta Neuropathologica·H B Jones, J B Cavanagh
Apr 1, 1994·Journal of Neurocytology·T Tandrup, H Braendgaard
May 13, 2008·Cell Biology and Toxicology·Amina E EssawyAmira E Hegazy
Jun 9, 2004·Neurotoxicology·Richard M LoPachin
Aug 8, 2002·Neurotoxicology·R M LoPachinE J Lehning
Jun 1, 1992·Neuropathology and Applied Neurobiology·T Tandrup, H Braendgaard
Aug 30, 2013·International Journal of Environmental Research and Public Health·Manuela PennisiMariano Malaguarnera
May 1, 1990·Toxicology and Applied Pharmacology·L N Berti-MatteraR M LoPachin
Dec 11, 1990·Toxicology and Applied Pharmacology·R M LoPachin, A J Saubermann
Jul 1, 1984·Neuropathology and Applied Neurobiology·A W BrownW N Aldridge
May 25, 2016·Environmental Science and Pollution Research International·Mamangam Subaraja, A J Vanisree
Apr 25, 2018·Journal of Veterinary Internal Medicine·Alexandra C E Draper, Richard J Piercy
Mar 1, 1992·Journal of Neuroscience Research·G J HarryT W Bouldin
Jan 18, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·P CeschiG Paasche
Apr 23, 2002·Journal of Cellular Biochemistry·Wen-Hsin HoHsiang-Shu Yin

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