Abstract
Acrylamide (30 mg or 50 mg/kg/day, 5 days each week) was injected intraperitoneally into rats for up to 4 weeks. Lumbar spinal ganglia, spinal cord and lumbrical muscle spindles were examined by light and electron microscopy at various times during this period. The first abnormalities in spinal ganglion neurons were seen at 7 days when an apparent increase in numbers of mitochondria, some being hypertrophic, were found in a few large light cells. This was 10 days before any significant Wallerian degeneration was found in muscle spindle sensory fibres. Mitochondrial changes became more marked with time and were later associated with RER disruption, loss of neurofilaments and peripheral displacement of the nucleus thus mimicking chromatolysis of the axon reaction. All these changes began, however, before axon degeneration. Evidence of increased satellite cell activity was maximal at 21 days. These changes are discussed in the light of the possibility that calcium entry into the cell may be seriously increased early in the intoxication as a direct result of the presence of acrylamide and that many of these cellular features are secondary responses to such an event. Distal degeneration of axons seems likely to be secondary to the p...Continue Reading
References
Oct 1, 1979·Acta Neuropathologica·J M JacobsJ B Cavanagh
Nov 9, 1979·Science·F A SchanneJ L Farber
May 1, 1977·The Histochemical Journal·D K Romanovicz, J S Hanker
Sep 1, 1976·Journal of the Neurological Sciences·J M JacobsJ B Cavanagh
May 16, 1973·Acta Neuropathologica·K Suzuki, L D Pfaff
Apr 1, 1974·Journal of Neuropathology and Experimental Neurology·H H SchaumburgP S Spencer
Jan 1, 1970·Acta Neuropathologica·A Bischoff
Sep 29, 1970·Brain Research·B G Cragg
Jan 1, 1971·International Review of Neurobiology·A R Lieberman
Oct 1, 1969·Journal of Neuropathology and Experimental Neurology·J Prineas
Apr 1, 1970·The Journal of Cell Biology·M A Grillo
Sep 1, 1970·Biochemical Pharmacology·K Hashimoto, W N Aldridge
Jul 1, 1982·Neuropathology and Applied Neurobiology·J B Cavanagh
Jul 1, 1982·Journal of Neuropathology and Experimental Neurology·A B Sterman
Sep 1, 1982·Neuropathology and Applied Neurobiology·J W GriffinH E Lowndes
Jan 1, 1982·Acta Neuropathologica·J B Cavanagh, C C Nolan
Mar 1, 1983·Journal of Neuropathology and Experimental Neurology·A B Sterman
Jun 1, 1983·Journal of Neurocytology·J B Cavanagh, M F Gysbers
Jul 1, 1982·Neuropathology and Applied Neurobiology·S Tassin, J M Brucher
Nov 1, 1981·Neuropathology and Applied Neurobiology·H B Jones, J B Cavanagh
Sep 1, 1960·Brain : a Journal of Neurology·G C SCHOFIELD
Sep 3, 1963·Zeitschrift für Zellforschung und mikroskopische Anatomie·E PANNESE
Jul 1, 1964·Journal of Neuropathology and Experimental Neurology·E A MACKEYJ WIENER
Citations
Jan 1, 1987·Acta Neuropathologica·I TéllezJ R Ricoy
Jan 1, 1986·Acta Neuropathologica·H B Jones, J B Cavanagh
Apr 1, 1994·Journal of Neurocytology·T Tandrup, H Braendgaard
Jan 1, 1992·Archives of Toxicology·B G GoldD L Price
May 13, 2008·Cell Biology and Toxicology·Amina E EssawyAmira E Hegazy
Apr 1, 1988·Toxicology·H B Jones
Jun 9, 2004·Neurotoxicology·Richard M LoPachin
Aug 8, 2002·Neurotoxicology·R M LoPachinE J Lehning
Jun 1, 1992·Neuropathology and Applied Neurobiology·T Tandrup, H Braendgaard
Aug 30, 2013·International Journal of Environmental Research and Public Health·Manuela PennisiMariano Malaguarnera
May 1, 1990·Toxicology and Applied Pharmacology·L N Berti-MatteraR M LoPachin
Dec 11, 1990·Toxicology and Applied Pharmacology·R M LoPachin, A J Saubermann
Nov 1, 1985·Neuropathology and Applied Neurobiology·L C TriarhouB Ghetti
Jul 1, 1984·Neuropathology and Applied Neurobiology·A W BrownW N Aldridge
May 25, 2016·Environmental Science and Pollution Research International·Mamangam Subaraja, A J Vanisree
Jan 1, 1986·Toxicologic Pathology·D J O'Shaughnessy, G J Losos
Apr 25, 2018·Journal of Veterinary Internal Medicine·Alexandra C E Draper, Richard J Piercy
Mar 1, 1987·Journal of Neurochemistry·M A Bisby, J D Redshaw
Jan 1, 1991·Cell Motility and the Cytoskeleton·M Hay, U De Boni
Mar 1, 1992·Journal of Neuroscience Research·G J HarryT W Bouldin
Jan 18, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·P CeschiG Paasche
Apr 23, 2002·Journal of Cellular Biochemistry·Wen-Hsin HoHsiang-Shu Yin
Jan 1, 1992·Molecular Neurobiology·G J Harry