PMID: 8588306May 1, 1995Paper

The evolution of morbilliviruses: a comparison of nucleocapsid gene sequences including a porpoise morbillivirus

Veterinary Microbiology
B K RimaJ A Earle

Abstract

Sequence data for the nucleocapsid protein (N) gene of the porpoise morbillivirus including the very conserved middle section of the protein and the hypervariable C terminus are reported. Analysis of dissimilarity indices based on an alignment of the N proteins of various morbilliviruses identifies a variable region of the N protein from amino acids residues 121 to 145 and a hypervariable part from amino acids 400 to 517. This type of analysis can be usefully applied when protein sequences of five or more morbillivirus species are available. Regions of variability between species identified by this index also represent regions of variation within one species e.g. measles virus (MV). Hence, comparative analysis of different morbilliviruses provides an insight into the potentially variable parts of viral proteins. From the great and unexplained nucleotide sequence conservation observed within MV, it would appear that the various morbilliviruses have diverged from each other a very long time ago. However, the data do not yet allow us to estimate the time span of these divergences. The relatedness and the number of different morbillivirus species provides a unique database for study of the evolution of RNA viruses.

References

Jan 1, 1991·Archives of Virology·S J McCulloughB K Rima
Nov 1, 1990·Nature·M DomingoB K Rima
Nov 3, 1988·Nature·S KennedyS McQuaid
Sep 1, 1988·Nature·A D Osterhaus, E J Vedder
Jun 2, 1994·Nature·P M Allen, R M Zinkernagel
Apr 1, 1993·The Journal of General Virology·I K VisserT Kuiken

❮ Previous
Next ❯

Citations

Jan 1, 1996·Virus Research·M Blixenkrone-MøllerV Svansson
Oct 12, 2013·Genome Announcements·Zhixun XieSisi Luo
Jul 29, 2004·Journal of Virology·Richard L KingstonLeslie S Gay
Feb 17, 2015·Viruses·Rory D de VriesRik L de Swart
Oct 11, 2015·Journal of Virological Methods·Carlos SacristánFernando Esperón
Jan 14, 2016·Diseases of Aquatic Organisms·Jessica M JacobBrenda A Jensen
Nov 10, 1998·Journal of Comparative Pathology·S Kennedy
Dec 17, 2008·Journal of Virological Methods·Rebecca J GrantCarlos H Romero
Jun 6, 2006·Journal of Virological Methods·Gabriella EliaCanio Buonavoglia
Apr 5, 2016·Current Microbiology·Barkha RattaBhaskar Sharma
Jun 20, 2012·Current Opinion in Virology·Rik L de SwartAlbert D M E Osterhaus
Apr 6, 2007·Reviews in Medical Virology·G J SipsN Wilczak
Jan 1, 1997·Journal of Virology·S LöfflerJ Schneider-Schaulies
Jun 6, 2021·Journal of Structural Biology·Luca ZinzulaWolfgang Baumeister

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.