The evolution of nerve growth factor inhibition in clinical medicine.

Nature Reviews. Rheumatology
Barton L WiseNancy E Lane

Abstract

Nerve growth factor (NGF) is a neurotrophin that activates nociceptive neurons to transmit pain signals from the peripheral to the central nervous system and that exerts its effects on neurons by signalling through tyrosine kinase receptors. Antibodies that inhibit the function of NGF and small molecule inhibitors of NGF receptors have been developed and tested in clinical studies to evaluate the efficacy of NGF inhibition as a form of analgesia in chronic pain states including osteoarthritis and chronic low back pain. Clinical studies in individuals with painful knee and hip osteoarthritis have revealed that NGF inhibitors substantially reduce joint pain and improve function compared with NSAIDs for a duration of up to 8 weeks. However, the higher tested doses of NGF inhibitors also increased the risk of rapidly progressive osteoarthritis in a small percentage of those treated. This Review recaps the biology of NGF and the studies that have been performed to evaluate the efficacy of NGF inhibition for chronic musculoskeletal pain states. The adverse events associated with NGF inhibition and the current state of knowledge about the mechanisms involved in rapidly progressive osteoarthritis are also discussed and future studies p...Continue Reading

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Citations

Aug 3, 2021·Frontiers in Neuroscience·Giuseppe AlastraGiovanni Tosi
Jul 25, 2021·BMC Musculoskeletal Disorders·Yuji YokozekiMasashi Takaso
Jul 30, 2021·Journal of Leukocyte Biology·Yating YiJun Wang
Jul 28, 2021·Nature Reviews. Rheumatology·Joanna Clarke
Oct 13, 2021·Postgraduate Medicine·Ryan Patel, Anthony H Dickenson
Nov 11, 2021·Science Translational Medicine·Selwyn JayakarClifford J Woolf
Nov 23, 2021·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Win Min Oo, David J Hunter

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