The evolution of posttranscriptional regulation.

Wiley Interdisciplinary Reviews. RNA
Bernhard SchaefkeWei Chen

Abstract

"DNA makes RNA makes protein." After transcription, mRNAs undergo a series of intertwining processes to be finally translated into functional proteins. The "posttranscriptional" regulation (PTR) provides cells an extended option to fine-tune their proteomes. To meet the demands of complex organism development and the appropriate response to environmental stimuli, every step in these processes needs to be finely regulated. Moreover, changes in these regulatory processes are important driving forces underlying the evolution of phenotypic differences across different species. The major PTR mechanisms discussed in this review include the regulation of splicing, polyadenylation, decay, and translation. For alternative splicing and polyadenylation, we mainly discuss their evolutionary dynamics and the genetic changes underlying the regulatory differences in cis-elements versus trans-factors. For mRNA decay and translation, which, together with transcription, determine the cellular RNA or protein abundance, we focus our discussion on how their divergence coordinates with transcriptional changes to shape the evolution of gene expression. Then to highlight the importance of PTR in the evolution of higher complexity, we focus on their ro...Continue Reading

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Citations

Jun 8, 2019·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Yue ZhangPingfang Yang
May 28, 2019·Wiley Interdisciplinary Reviews. RNA·Aparna KishorJ Robert Hogg
Mar 16, 2019·Frontiers in Plant Science·Rafael CataláJulio Salinas
Mar 9, 2019·Wiley Interdisciplinary Reviews. RNA·Sarah A PeckAmber L Mosley
Nov 13, 2020·Nature·Zhong-Yi WangHenrik Kaessmann
Dec 4, 2020·Nature Reviews. Genetics·Mark S HillPatricia J Wittkopp
Jan 20, 2019·Developmental Biology·Andreas ZauckerKaruna Sampath
Nov 11, 2021·Applied and Environmental Microbiology·Martin SperfeldEinat Segev

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