The evolution of tachykinin/tachykinin receptor (TAC/TACR) in vertebrates and molecular identification of the TAC3/TACR3 system in zebrafish (Danio rerio)

Molecular and Cellular Endocrinology
Wenyi ZhouHaoran Lin

Abstract

Tachykinins are a family of peptides that are conserved from invertebrates to mammals. However, little is known about the evolutionary history of tachykinin (TAC) and tachykinin receptor (TACR) genes in vertebrates, especially in the teleost group. In the present study, five TACs and six TACRs genes were identified in the zebrafish genome. Genomic synteny analysis and phylogenetic tree analysis indicate that the increased numbers of TAC and TACR genes in vertebrates are the result of both genome duplications and local individual gene duplication. The full-length cDNA sequences encoding multiple TAC3s (TAC3a and TAC3b) and TACR3s (TACR3a1, TACR3a2 and TACR3b) were subsequently cloned from zebrafish brain samples. Sequence analysis suggested that four putative neurokinin B (NKB)-like peptides (NKBa-13, NKBa-10, NKBb-13 and NKBb-11) might be generated by the processing of two zebrafish TAC3 precursors. Tissue distribution studies in zebrafish revealed that TAC3 and TACR3 are mainly expressed in the brain regions. The biological activities of four zebrafish NKB peptides and three TACR3s were further examined using transcription reporter assays in cultured eukaryotic cells. All the synthetic NKB peptides were able to evoke the downs...Continue Reading

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Citations

Aug 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Hongbo JiangYoung-Joon Kim
Dec 22, 2012·Journal of Molecular Endocrinology·Roger López-BellidoRaquel E Rodríguez
Aug 31, 2014·General and Comparative Endocrinology·Guangfu HuAnderson O L Wong
Jun 13, 2013·General and Comparative Endocrinology·Nerine T JosephRobert P Millar
Mar 27, 2013·Neuroscience·Roger López-BellidoRaquel Emilia Rodríguez
Dec 3, 2014·General and Comparative Endocrinology·Xin QiHaoran Lin
Aug 29, 2014·Frontiers in Endocrinology·Seongsik YunJae Young Seong
Jan 16, 2019·The Journal of Comparative Neurology·Julie M Butler, Karen P Maruska
Dec 28, 2018·International Journal of Molecular Sciences·Xiangfeng QinGuangfu Hu
Jul 30, 2019·Frontiers in Endocrinology·Naama MizrahiBerta Levavi-Sivan
Feb 8, 2020·General and Comparative Endocrinology·José A Muñoz-CuetoYonathan Zohar
Jun 29, 2021·General and Comparative Endocrinology·Yu LiYong Zhang
Sep 15, 2020·ACS Chemical Neuroscience·Wen-Wen ZhangYu-Xia Chu
Jun 5, 2021·General and Comparative Endocrinology·Shaohua XuGuangfu Hu

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