The evolution of the human genome

Current Opinion in Genetics & Development
Corinne N Simonti, John A Capra

Abstract

Human genomes hold a record of the evolutionary forces that have shaped our species. Advances in DNA sequencing, functional genomics, and population genetic modeling have deepened our understanding of human demographic history, natural selection, and many other long-studied topics. These advances have also revealed many previously underappreciated factors that influence the evolution of the human genome, including functional modifications to DNA and histones, conserved 3D topological chromatin domains, structural variation, and heterogeneous mutation patterns along the genome. Using evolutionary theory as a lens to study these phenomena will lead to significant breakthroughs in understanding what makes us human and why we get sick.

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Citations

Apr 21, 2016·Mobile DNA·Maximilian KotheOliver Piskurek
Sep 16, 2019·Plant Science : an International Journal of Experimental Plant Biology·Benildo G de Los Reyes
Mar 2, 2021·Frontiers in Genetics·Inês LopesJoão Pedro de Magalhães

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