The evolution of three types of indoleamine 2,3 dioxygenases in fungi with distinct molecular and biochemical characteristics

Gene
H J Yuasa, Helen J Ball

Abstract

Indoleamine 2,3-dioxygenase (IDO) is a tryptophan-degrading enzyme and known as a mammalian immunosuppressive molecule. In fungi, the primary role of IDO is to supply nicotinamide adenine dinucleotide (NAD(+)) via the kynurenine pathway. We previously reported that the koji-mold, Aspergillus oryzae has two IDO genes, IDOα and IDOβ. In the present study, we found that A. oryzae also has the third IDO, IDOγ. These three-types of IDOs are widely distributed among the Pezizomycotina fungi, although the black truffle, Tuber melanosporum has only one corresponding gene to IDOα/IDOβ. The yeast, Saccharomyces cerevisiae has a single IDO gene. Generally, Pezizomycotina IDOα showed similar enzymatic properties to the yeast IDO, suggesting that the IDOα is a functional homologue of the S. cerevisiae IDO. In contrast to IDOα, the K(m) value of IDOβ is higher. However, the reaction velocity of IDOβ is very fast, resulting in comparable or higher catalytic efficiency than IDOα. Thus IDOβ may functionally substitute for IDOα in fungal L-Trp metabolism. The enzymatic activity of IDOγ was comparatively very low with the values of enzymatic parameters comparable to vertebrate IDO2 enzymes. IDOα and IDOβ have similar gene structures, suggesting t...Continue Reading

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Citations

Aug 30, 2014·Genome Biology and Evolution·Chad M Ternes, Gerald Schönknecht
Dec 23, 2015·Future Medicinal Chemistry·Francesco Antonio GrecoAntonio Macchiarulo
Dec 25, 2015·Fungal Genetics and Biology : FG & B·Pin-Mei WangNancy P Keller
Feb 24, 2015·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Hajime J Yuasa, Helen J Ball
Oct 28, 2014·Frontiers in Immunology·Helen J BallHajime J Yuasa
Dec 3, 2016·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Emma L Raven
Dec 14, 2018·Frontiers in Molecular Biosciences·Mirco DindoBarbara Cellini
Jul 6, 2019·Biochimica Et Biophysica Acta. Proteins and Proteomics·Hajime Julie Yuasa

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