PMID: 9555610Apr 29, 1998Paper

The evolution of treatment resistance: biologic implications

Journal of Clinical Psychopharmacology
H Y MeltzerP A Cola

Abstract

The evolution of resistance of positive symptoms to antipsychotic therapy may represent a valuable means of subtyping schizophrenia. In contrast, resistance of negative symptoms and cognitive function to antipsychotic agents seems to be present from the first episode of psychotic symptoms and does not evolve over time to the same extent. If these findings are validated, this clearly points toward differences in the etiology of these components of schizophrenia. Data from a cohort of 223 patients with unsatisfactory responses to classical antipsychotic therapy are evaluated, at least 60% of whom responded to subsequent treatment with clozapine. Comparisons were made between the subgroups of patients with primary and delayed onset treatment resistance. Both subgroups responded to clozapine therapy, although better response was evident for patients with delayed resistance. The withdrawal of clozapine from patients who had previously been responsive to classical antipsychotic therapy was capable of inducing treatment resistance.

Citations

Jun 16, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·C D AdvokatJ E Comaty
Jan 7, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·B GrassiS Scarone
Apr 17, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jimmi NielsenDavid Taylor
Sep 17, 2014·Schizophrenia Research·Jiang Li, Herbert Y Meltzer
Feb 24, 2001·Journal of Psychopharmacology·D M Taylor, D Duncan-McConnell
Jan 1, 2006·International Journal of Psychiatry in Clinical Practice·Tanveer SobhanWilliam G Ryan
Sep 26, 2012·Clinical Schizophrenia & Related Psychoses·Herbert Y Meltzer
Dec 18, 2001·Biological Psychiatry·R R Conley, D L Kelly

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

© 2022 Meta ULC. All rights reserved