The evolutionary fate of the genes encoding the purine catabolic enzymes in hominoids, birds, and reptiles.

Molecular Biology and Evolution
Alaine C Keebaugh, James W Thomas

Abstract

Gene loss has been proposed to play a major role in adaptive evolution, and recent studies are beginning to reveal its importance in human evolution. However, the potential consequence of a single gene-loss event upon the fates of functionally interrelated genes is poorly understood. Here, we use the purine metabolic pathway as a model system in which to explore this important question. The loss of urate oxidase (UOX) activity, a necessary step in this pathway, has occurred independently in the hominoid and bird/reptile lineages. Because the loss of UOX would have removed the functional constraint upon downstream genes in this pathway, these downstream genes are generally assumed to have subsequently deteriorated. In this study, we used a comparative genomics approach to empirically determine the fate of UOX itself and the downstream genes in five hominoids, two birds, and a reptile. Although we found that the loss of UOX likely triggered the genetic deterioration of the immediate downstream genes in the hominoids, surprisingly in the birds and reptiles, the UOX locus itself and some of the downstream genes were present in the genome and predicted to encode proteins. To account for the variable pattern of gene retention and los...Continue Reading

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Citations

Sep 12, 2013·Journal of Molecular Microbiology and Biotechnology·Anke Trautwein-SchultGotthard Kunze
Apr 26, 2011·Journal of Molecular Biology·Laura CendronRodolfo Berni
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Aug 19, 2020·Asian-Australasian Journal of Animal Sciences·Xuedong DingJinjie Wu
Oct 2, 2021·Frontiers in Endocrinology·Zijing RanChanggui Li

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