The evolutionary history of grey wolf Y chromosomes

Molecular Ecology
Linnéa SmedsH Ellegren

Abstract

Analyses of Y chromosome haplotypes uniquely provide a paternal picture of evolutionary histories and offer a very useful contrast to studies based on maternally inherited mitochondrial DNA (mtDNA). Here we used a bioinformatic approach based on comparison of male and female sequence coverage to identify 4.7 Mb from the grey wolf (Canis lupis) Y chromosome, probably representing most of the male-specific, nonampliconic sequence from the euchromatic part of the chromosome. We characterized this sequence and then identified ≈1,500 Y-linked single nucleotide polymorphisms in a sample of 145 resequenced male wolves, including 75 Finnish wolf genomes newly sequenced in this study, and in 24 dogs and eight other canids. We found 53 Y chromosome haplotypes, of which 26 were seen in grey wolves, that clustered in four major haplogroups. All four haplogroups were represented in samples of Finnish wolves, showing that haplogroup lineages were not partitioned on a continental scale. However, regional population structure was indicated because individual haplotypes were never shared between geographically distant areas, and genetically similar haplotypes were only found within the same geographical region. The deepest split between grey wo...Continue Reading

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Citations

May 31, 2019·Genes·Halie M RandoAnna V Kukekova
Sep 2, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Patrik GaletaMietje Germonpré
Aug 14, 2020·Genome Biology and Evolution·Mónica Martínez-PachecoDiego Cortez
Mar 27, 2021·Evolutionary Applications·Linnéa SmedsHans Ellegren

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Datasets Mentioned

BETA
KP081776.1
ERR868147

Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

jmodeltest
bedtools
bwa
popart
igv
GATK
hisat2
PhoCS
TreeAnnotator
RepeatMasker

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