The evolving relationship of wound healing and tumor stroma

JCI Insight
Deshka S FosterJeffrey A Norton

Abstract

The stroma in solid tumors contains a variety of cellular phenotypes and signaling pathways associated with wound healing, leading to the concept that a tumor behaves as a wound that does not heal. Similarities between tumors and healing wounds include fibroblast recruitment and activation, extracellular matrix (ECM) component deposition, infiltration of immune cells, neovascularization, and cellular lineage plasticity. However, unlike a wound that heals, the edges of a tumor are constantly expanding. Cell migration occurs both inward and outward as the tumor proliferates and invades adjacent tissues, often disregarding organ boundaries. The focus of our review is cancer associated fibroblast (CAF) cellular heterogeneity and plasticity and the acellular matrix components that accompany these cells. We explore how similarities and differences between healing wounds and tumor stroma continue to evolve as research progresses, shedding light on possible therapeutic targets that can result in innovative stromal-based treatments for cancer.

References

Apr 1, 1991·Journal of Cellular Biochemistry
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P Garin-ChesaW J Rettig
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A B RobertsJ H Kehrl
Jan 1, 1983·Cancer Metastasis Reviews·H F DvorakA M Dvorak
Jul 1, 1995·The Journal of Cell Biology·F StrutzE G Neilson
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·M SantraR V Iozzo
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A L PrietoK L Crossin
Jul 25, 1996·The New England Journal of Medicine·L E HanssonH O Adami
Feb 15, 1996·The Biochemical Journal·K BittnerH Kresse
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Sep 13, 2001·Molecular Biology of the Cell·B HinzC Chaponnier
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Aug 29, 2003·Biochemical and Biophysical Research Communications·Genichiro IshiiAtsushi Ochiai
Sep 3, 2004·The Journal of Clinical Investigation·Enrico GiraudoDouglas Hanahan
Sep 7, 2004·The International Journal of Developmental Biology·Alexis DesmoulièreGiulio Gabbiani
Nov 2, 2004·Nature Reviews. Cancer·Margareta M Mueller, Norbert E Fusenig
Feb 4, 2005·Oncogene·Charles C ReedRenato V Iozzo
Apr 22, 2005·The Journal of Biological Chemistry·Ben FogelgrenKatalin Csiszar
May 4, 2005·Cancer Research·Birgitte Grum-SchwensenNoona Ambartsumian
Jul 15, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Susan R Opalenik, Jeffrey M Davidson
Sep 20, 2005·Cancer Cell·Matthew J PaszekValerie M Weaver
Dec 13, 2005·Expert Review of Anticancer Therapy·Keiran S M SmalleyMeenhard Herlyn
Mar 31, 2006·Nature Reviews. Cancer·Raghu Kalluri, Michael Zeisberg
Apr 28, 2006·Nature·Janine T ErlerAmato J Giaccia
Aug 2, 2006·Cell Cycle·Akira Orimo, Robert A Weinberg
Aug 31, 2006·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Hannu JärveläinenThomas N Wight
Oct 31, 2006·The Journal of Investigative Dermatology. Symposium Proceedings·Beate EckesThomas Krieg
Nov 16, 2006·Cancer Biology & Therapy·Hikaru SugimotoRaghu Kalluri

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Citations

Mar 26, 2019·The FEBS Journal·Achilleas D TheocharisNikos K Karamanos
Oct 9, 2019·International Journal of Molecular Sciences·Mayra Paolillo, Sergio Schinelli
Jan 9, 2020·Journal of Hematology & Oncology·Go J Yoshida
Jan 5, 2020·Cellular and Molecular Life Sciences : CMLS·Amanda L PatchettGregory M Woods
May 19, 2020·Cell Adhesion & Migration·Miguel Gonzalez-AndradesPablo Argüeso
May 14, 2020·Nature Reviews. Clinical Oncology·Won Jin HoLei Zheng
Jul 28, 2020·Nature Reviews. Clinical Oncology·Rik DerynckRosemary J Akhurst
Jul 17, 2020·Cancers·Francesco BonolloSofia Karkampouna
May 21, 2019·Frontiers in Cell and Developmental Biology·Tianyi LiuYuhang Zhang
Nov 20, 2019·International Journal of Molecular Sciences·Angelo Giuseppe CondorelliDaniele Castiglia
Jun 18, 2020·Journal of Experimental & Clinical Cancer Research : CR·Go J Yoshida
Sep 10, 2020·Science Signaling·Lucy MacCarthy-Morrogh, Paul Martin
Jan 14, 2021·Biomaterials Science·Kanishka FernandoEliza Li Shan Fong
Oct 18, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Mariella TutterChristine Spitzweg
Oct 29, 2020·Scientific Reports·Irene RomayorElvira Olaso
Nov 5, 2020·International Journal of Molecular Sciences·Irina DruzhkovaEugene Sverdlov
Feb 10, 2021·Journal for Immunotherapy of Cancer·Rafael Moreno
Dec 3, 2020·Frontiers in Immunology·Gizem DuruNiels Heemskerk
Feb 17, 2021·Nature Reviews. Cancer·Thomas R Cox
Jan 26, 2021·Biomaterials·Kelsey G DeFratesPhillip B Messersmith
Dec 10, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anne S Ten HoveWouter J de Jonge
Mar 30, 2021·EMBO Reports·Lisette Van HoveEsther Hoste
Apr 4, 2021·Cancers·Elysia RacanelliElena Netchiporouk
Jan 27, 2021·Biofabrication·David J BustamanteNicanor I Moldovan
Jun 1, 2021·Journal of Tissue Engineering and Regenerative Medicine·Daniela Santos Masson-Meyers, Lobat Tayebi
Jul 25, 2021·Cancers·Ana Maia, Stefan Wiemann
Aug 8, 2021·International Journal of Molecular Sciences·Marina MarozziFederica Rizzi
Feb 12, 2020·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Aleksandra SejdaEwa Iżycka-Świeszewska

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Methods Mentioned

BETA
proteomic profiling
RNA-seq
biopsy

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