The evolving role of immune oncology in colorectal cancer

Chinese Clinical Oncology
Shaheenah Dawood

Abstract

Metastatic colorectal cancer still remains an essentially non curable disease. However, with advances in chemotherapeutic and personalizing therapeutic approaches with the incorporation of targeted therapy such as anti-EGFR and anti-VEGF agents survival associated with metastatic colorectal cancer has certainly improved over the last two decades. Patients who are not amenable to surgery median survival remain approximately 2 to 3 years. In an attempt to improve prognostic outcome over the last decade research has focused on therapeutic options geared towards harnessing the immune system with success observed with the use of immune checkpoint inhibitors in the realm of a number of solid tumors including lung and renal cancer. The use of immunomodulatory therapeutic approaches for the management of unselected advanced colorectal cancer has not seen the same success with low response rates reported. The turning point was our recent understanding that efficacy of immunotherapy was limited to a subset of patients with hyper mutated microsatellite instability-high (MSI-H) tumors. This review will focus on summarizing available knowledge on the immunological and molecular landscape of colorectal cancer that can help determine subsets ...Continue Reading

Citations

Nov 23, 2018·International Journal of Colorectal Disease·Pawel Wrobel, Shahid Ahmed
Jul 10, 2020·Human Vaccines & Immunotherapeutics·Tianrui YangWenbin Ma
Feb 25, 2020·BioMed Research International·Malek KreidiehAli Shamseddine
Dec 12, 2018·Journal of Cellular Biochemistry·Mostafa SarvizadehMohsen Taghizadeh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Related Papers

Journal of the National Comprehensive Cancer Network : JNCCN
Katherine M Bever, Dung T Le
Journal of Gastrointestinal Oncology
Aparna KalyanA Benson
© 2022 Meta ULC. All rights reserved