The evolving role of TonEBP as an immunometabolic stress protein.

Nature Reviews. Nephrology
Soo Youn ChoiH Moo Kwon

Abstract

Tonicity-responsive enhancer-binding protein (TonEBP), which is also known as nuclear factor of activated T cells 5 (NFAT5), was discovered 20 years ago as a transcriptional regulator of the cellular response to hypertonic (hyperosmotic salinity) stress in the renal medulla. Numerous studies since then have revealed that TonEBP is a pleiotropic stress protein that is involved in a range of immunometabolic diseases. Some of the single-nucleotide polymorphisms (SNPs) in TONEBP introns are cis-expression quantitative trait loci that affect TONEBP transcription. These SNPs are associated with increased risk of type 2 diabetes mellitus, diabetic nephropathy, inflammation, high blood pressure and abnormal plasma osmolality, indicating that variation in TONEBP expression might contribute to these phenotypes. In addition, functional studies have shown that TonEBP is involved in the pathogenesis of rheumatoid arthritis, atherosclerosis, diabetic nephropathy, acute kidney injury, hyperlipidaemia and insulin resistance, autoimmune diseases (including type 1 diabetes mellitus and multiple sclerosis), salt-sensitive hypertension and hepatocellular carcinoma. These pathological activities of TonEBP are in contrast to the protective actions o...Continue Reading

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Citations

Jun 23, 2020·PLoS Biology·Patrick NeubertJonathan Jantsch
Jun 6, 2020·Cell Death & Disease·Byeong Jin YeHyug Moo Kwon
Oct 6, 2020·Journal of Diabetes Research·Lusha CenYi Cao
Oct 3, 2020·Nature Reviews. Nephrology·Adriana MartonJens Titze
Dec 15, 2020·Nucleic Acids Research·Hyun Je KangHyug Moo Kwon
Jan 14, 2021·International Journal of Molecular Sciences·Agnes SchröderChristian Kirschneck
Nov 5, 2020·Immunology and Cell Biology·Matthew J SweetJames Harris
May 1, 2021·International Journal of Molecular Sciences·Caini FanPrasad R Konkalmatt
May 9, 2021·Trends in Immunology·Katarzyna JobinChristian Kurts
May 29, 2021·DNA Repair·Byeong Jin YeSoo Youn Choi
Jul 9, 2021·Journal of Experimental & Clinical Cancer Research : CR·Dmitry ChernyakovBayram Edemir
Aug 13, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lena KappertThomas Korff
Aug 7, 2021·The FEBS Journal·Giacomo Rossitto, Christian Delles
Sep 28, 2021·Frontiers in Immunology·Luka KrampertJonathan Jantsch

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Methods Mentioned

BETA
nuclear translocation
sumoylation
tandem-affinity purification
acetylation

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