The Evolving Story of Autoantibodies in Pemphigus Vulgaris: Development of the "Super Compensation Hypothesis"

Frontiers in Medicine
Animesh A Sinha, Thomas Sajda

Abstract

Emerging data and innovative technologies are re-shaping our understanding of the scope and specificity of the autoimmune response in Pemphigus vulgaris (PV), a prototypical humorally mediated autoimmune skin blistering disorder. Seminal studies identified the desmosomal proteins Desmoglein 3 and 1 (Dsg3 and Dsg1), cadherin family proteins which function to maintain cell adhesion, as the primary targets of pathogenic autoAbs. Consequently, pathogenesis in PV has primarily considered to be the result of anti-Dsg autoAbs alone. However, accumulating data suggesting that anti-Dsg autoAbs by themselves cannot adequately explain the loss of cell-cell adhesion seen in PV, nor account for the disease heterogeneity exhibited across PV patients has spurred the notion that additional autoAb specificities may contribute to disease. To investigate the role of non-Dsg autoAbs in PV, an increasing number of studies have attempted to characterize additional targets of PV autoAbs. The recent advent of protein microarray technology, which allows for the rapid, highly sensitive, and multiplexed assessment of autoAb specificity has facilitated the comprehensive classification of the scope and specificity of the autoAb response in PV. Such detaile...Continue Reading

References

Aug 1, 1976·The Journal of Investigative Dermatology·J R Schiltz, B Michel
Jan 1, 1987·Archives of Dermatological Research·C PicutR Lewis
Jan 1, 1989·Autoimmunity·P WadeleuxR Winand
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J C JonesR D Goldman
Feb 1, 1985·The British Journal of Dermatology·E Acosta, L Ivanyi
Nov 1, 1973·The Journal of Investigative Dermatology·S Y Shu, E H Beutner
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J C JonesR D Goldman
Aug 1, 1984·The Journal of Clinical Investigation·J R StanleyC Thivolet
May 20, 1982·The New England Journal of Medicine·G J AnhaltL A Diaz
Aug 1, 1982·The Journal of Clinical Investigation·J R StanleyS I Katz
Dec 1, 1995·The Journal of Investigative Dermatology·S A GrandoB M Conti-Fine
Jan 1, 1995·The Journal of Investigative Dermatology·S A GrandoM V Dahl
Oct 1, 1995·The British Journal of Dermatology·M DmochowskiD R Garrod
Jan 1, 1995·Annual Review of Neuroscience·U Suter, G J Snipes
Jan 1, 1995·European Journal of Endocrinology·U BognerH Schleusener
Dec 1, 1993·The Journal of Clinical Endocrinology and Metabolism·L ChiovatoA Pinchera
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·S M TroyanovskyW W Franke
Aug 1, 1994·The Journal of Clinical Endocrinology and Metabolism·A B ParkesJ H Lazarus
Sep 1, 1994·Journal of the American Academy of Dermatology·A FiroozA R Ahmed
Sep 1, 1993·The British Journal of Dermatology·J K ShornickM M Black
Jul 1, 1996·The Journal of Clinical Endocrinology and Metabolism·P RodienJ Orgiazzi
Sep 1, 1996·The Journal of Investigative Dermatology·A P KowalczykK J Green
Dec 6, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M A ChidgeyD R Garrod

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Citations

Jan 29, 2020·The American Journal of Dermatopathology·Randie H Kim, Nooshin K Brinster
Aug 21, 2020·British Journal of Pharmacology·Imke A K BurmesterRalf J Ludwig
Jul 6, 2019·Frontiers in Immunology·Giulia Di LulloGiovanni Di Zenzo
Jul 12, 2019·Frontiers in Immunology·Dario DidonaMichael Hertl
Dec 16, 2019·American Journal of Clinical Dermatology·James E Frampton
Apr 20, 2019·Frontiers in Immunology·Rikard HolmdahlRalf J Ludwig
Oct 3, 2019·Expert Review of Clinical Immunology·Rebecca L YanovskyA Razzaque Ahmed
Jul 6, 2019·Frontiers in Immunology·Roberta LottiCarlo Pincelli
Jan 29, 2021·Frontiers in Immunology·Katja BieberRalf J Ludwig
Apr 13, 2021·Frontiers in Immunology·Khalaf KridinRalf J Ludwig
Apr 2, 2021·The British Journal of Dermatology·T SchmittJ Waschke

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Methods Mentioned

BETA
phage display
ELISAs
immunoprecipitation
ELISA
protein array
protein array technology
biopsies
protein
dissection

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