The Ex Vivo Eye Irritation Test (EVEIT) in evaluation of artificial tears: Purite-preserved versus unpreserved eye drops.

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Norbert F SchrageF Spoeler

Abstract

Preservatives in artificial tears cause controversy. New developments such as the Purite system have been introduced into the market, with the promise of little damage to the corneal surface. We wanted to give insight into the differences in the effect of preserved and unpreserved artifical tears on rabbit corneas cultured with the Ex Vivo Eye Irritation Test (EVEIT) system. We compared the two artifical tears products Hylo Comod and Optive being dropped for 72 hours each hour one drop onto the corneal surface. Each cornea was mechanically wounded with four epithelial defects on each cornea with a size of 3 to 4.5 mm(2). With n = 4 corneas in the Hylo-Comod and n = 4 corneas in the Optive group, we exposed the corneal surfaces to repeated doses of these artificial tears for 3 days. We observed healing of corneal erosions and surface epithelial integrity with sodium-fluoresceine staining under cobalt blue light illumination. We found nearly complete healing of epithelial defects with both artificial tears. The Hylo-Comod group healed significantly faster. After 72 hours, the vast majority of epithelial defects were closed. All corneas exposed to Purite showed superficial stippling, whereas the HyloComod group did not show any st...Continue Reading

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Citations

Dec 18, 2013·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·K BellF H Grus
May 23, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·R M DutescuN Schrage
Aug 20, 2015·Current Eye Research·Ahmet M HondurBahri Aydin
Jan 30, 2015·Bioprocess and Biosystems Engineering·Andreas Christoph Apel, Dirk Weuster-Botz
Jul 15, 2015·Journal of Glaucoma·Ralph PinheiroR Michael Dutescu
Mar 20, 2015·Cornea·Ralf M DutescuNorbert Schrage
Jun 27, 2019·Alternatives to Laboratory Animals : ATLA·Sven SchnichelsStephanie C Joachim
Nov 13, 2020·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Ralf M DutescuNorbert Schrage
May 19, 2021·Translational Vision Science & Technology·Damien GuindoletGilles Thuret
Jul 16, 2021·Eye·Michael H GoldsteinSrilatha Vantipalli
Oct 15, 2021·Journal of Applied Toxicology : JAT·Noémie BonneauFrançoise Brignole-Baudouin

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