The examination of skin lipid model systems stressed by ultraviolet irradiation in the presence of transition metal ions

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
H TrommerReinhard H H Neubert

Abstract

In this study, we investigated the effects of ultraviolet (UV) radiation on lipid peroxidation in the presence of ionised iron as a transition metal. Fatty acids as important intercellular stratum corneum lipids and liposomes were used to model skin lipid systems for our experiments. A UV-A laser and a broad spectrum UV lamp were used to create high-level radiation. UV-related damage was quantified by the thiobarbituric acid assay detecting malondialdehyde. Electrospray mass spectrometry was used to characterise peroxidation products following UV exposure. We have shown that hydro- and endoperoxides are long stable intermediates deriving from lipid peroxidation. The incorporation of unsaturated fatty acids into phospholipid liposomes increased the average liposomal diameter and enhanced sensitivity to UV radiation. By comparing our data from laser induced monochromatic UV-A radiation and broad-spectrum UV irradiation, we have demonstrated that UV-A radiation can also induce lipid peroxidation in lipid model systems.

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Citations

Jun 16, 2005·International Journal of Pharmaceutics·Hagen Trommer, Reinhard H H Neubert
Mar 8, 2003·International Journal of Pharmaceutics·Hagen TrommerReinhard H H Neubert
Apr 16, 2008·Chemistry and Physics of Lipids·C MerleA Baillet-Guffroy
Jun 24, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·G M El MaghrabyA C Williams
Aug 17, 2005·The Journal of Pharmacy and Pharmacology·Hagen TrommerReinhard H H Neubert
Aug 30, 2007·The Journal of Pharmacy and Pharmacology·Sabrina NarayananReinhard H H Neubert
Jan 11, 2013·Journal of Mass Spectrometry : JMS·Tânia MeloM Rosário M Domingues
Sep 25, 2015·International Journal of Cosmetic Science·Yanli Li, Cheng Yang
Feb 23, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Irma LiascukieneJean-François Lambert
Aug 6, 2021·Chemistry and Physics of Lipids·Benedetta PetraccaJoke A Bouwstra
Jan 6, 2005·Journal of Agricultural and Food Chemistry·Janina GabrielskaStanisław Przestalski
Sep 28, 2006·Journal of Agricultural and Food Chemistry·Janina GabrielskaStanisław Przestalski

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