The excretion of carbonic anhydrase isozymes CA I and CA II in the urine of apparently healthy subjects and in patients with kidney disease

Scandinavian Journal of Clinical and Laboratory Investigation
U BackmanP J Wistrand

Abstract

Carbonic anhydrase isozymes CA I and CA II were assayed by a radio-immunosorbent technique in the plasma and urine of apparently healthy subjects and of patients with renal disease. The concentrations (mean +/- SD, n = 8) of CA I and CA II in the plasma of healthy subjects were 2.3 +/- 2.3 and 0.8 +/- 0.5 mg/l, respectively. The urinary excretion values were 3.8 +/- 2.0 and 3.5 +/- 1.9 micrograms/24 h, and the apparent renal clearances were 21 +/- 17 and 52 +/- 44 microliters/min, respectively, values that are similar to those of other low molecular weight proteins. CA I and CA II have mol. wt of 28,850 and 29,300, respectively, they are globular in shape and have a Stoke-Einstein radius of 25 A. They could, therefore, be expected to be filtered at the glomeruli and thereafter reabsorbed by the proximal tubules. CA II is also present in the cytoplasm of renal proximal and distal tubular cells. A study of the pattern of urinary excretion of CA I and CA II could permit detection of damage to renal tubular cells in two ways--either from defective reabsorption of filtered CA I and CA II by the proximal tubular cells, or from leakage of CA II from the proximal or distal tubules into the urine. Some patients with hypercalcuria and re...Continue Reading

References

Oct 1, 1979·Scandinavian Journal of Clinical and Laboratory Investigation·T WåhlstrandP J Wistrand
May 7, 1976·Analytical Biochemistry·N TaniguchiE Takakuwa
Aug 30, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·T KumpulainenL K Korhonen
Feb 21, 1967·Biochimica Et Biophysica Acta·J R PoortmansK Schmid
Oct 1, 1967·Physiological Reviews·T H Maren
Jun 1, 1984·Kidney International·G Lönnerholm, P J Wistrand
May 1, 1956·The American Journal of Physiology·B K OCHWADT, R F PITTS
Jun 1, 1955·The American Journal of Medicine·T H HAM
Jan 14, 1938·The Journal of Physiology·V H Booth

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Citations

Mar 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·O Wrong
Aug 24, 2002·Acta Physiologica Scandinavica·Y RidderstråleP J Wistrand
Jun 13, 2020·The Journal of Applied Laboratory Medicine·Alzbeta HulikovaPawel Swietach

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