The excretion of pesticides in saliva and its value in assessing exposure

Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
J F Borzelleca, H L Skalsky

Abstract

The possibility that pesticides are secreted in the saliva and that this secretion can be used to assess exposure to pesticides is discussed. Both Kepone and carbaryl were tested through a series of in vitro studies and in vivo experiments including both acute and subchronic studies. In the in vivo studies, both Kepone and carbaryl were detected in the saliva in the first twenty-four hours, but seldom thereafter. Analysis of urinary samples indicated a rapid clearance of the substances from the animals. In vitro uptake and efflux studies suggested that movement of both substances was by passive diffusion and reached a plateau after 60 minutes of incubation. Efflux rates were unaffected by experimental conditions, but were ten times faster for carbaryl.

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Citations

Nov 20, 2008·Journal of Exposure Science & Environmental Epidemiology·Richard C BarryCharles A Timchalk
Jun 9, 2006·Environmental Health Perspectives·Dana B BarrJohn Acquavella
Jun 16, 2015·Frontiers in Pharmacology·Charles TimchalkJordan N Smith
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Aug 26, 2018·Environmental Science and Pollution Research International·Damien A DevaultSébastien Bristeau

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