PMID: 8962719Jan 1, 1996Paper

The exogenous administration of basic fibroblast growth factor to regenerating skeletal muscle in mice does not enhance the process of regeneration

Growth Factors
C A MitchellM D Grounds

Abstract

The effects, in vivo, of the exogenous administration of bFGF on myogenesis of regenerating skeletal muscle was assessed either morphometrically or autoradiographically in three separate models of muscle injury in mice: crush-injured, denervated, and dystrophic (mdx) muscles. The bFGF was administered at various doses and different time schedules, sometimes in combination with heparin, into injured tibialis anterior muscles of mice. Delivery of the bFGF was either by direct intramuscular injection or by the sustained release from 888polymers (Hydron or Elvax) implanted into the muscles. The bioactivity of bFGF was confirmed in vitro by measuring its ability to stimulate the proliferation of BALB/c-3T3 fibroblasts and muscle precursor cell lines. The ability of bFGF to stimulate angiogenesis in vivo was confirmed by the implantation of controlled-release polymers containing bFGF into the normally avascular cornea of rats. No measurable effect of bFGF was seen in any of the models of skeletal muscle injury under these experimental conditions, indicating that the availability of biologically active bFGF is not a limiting factor in the regeneration of skeletal muscle following injury.

References

Dec 1, 1992·Journal of Cellular Physiology·G Chen, L S Quinn
Oct 1, 1990·Journal of Structural Biology·T A RobertsonJ M Papadimitriou
Feb 14, 1990·Biochemical and Biophysical Research Communications·J AlterioI Martelly
Jan 1, 1988·Neuropathology and Applied Neurobiology·G R CoultonJ C Sloper
Mar 1, 1988·Developmental Biology·E KardamiR C Strohman
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·I VlodavskyM Klagsbrun
Sep 1, 1986·Journal of Cellular Physiology·D Gospodarowicz, J Cheng
Aug 1, 1987·Journal of the Neurological Sciences·J W Carnwath, D M Shotton
Oct 1, 1987·Cell and Tissue Research·M D Grounds, J K McGeachie
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·F EschR Guillemin
Dec 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·D Gospodarowicz, J Moran
Aug 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R Dilley, J McGeachie
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G BulfieldK J Moore
Sep 1, 1994·Developmental Dynamics : an Official Publication of the American Association of Anatomists·R Bischoff, C Heintz
Jan 1, 1994·Progress in Growth Factor Research·B B OlwinA J Kudla
Jan 1, 1993·Molecular and Cell Biology of Human Diseases Series·M D Grounds, Z Yablonka-Reuveni
Nov 1, 1993·Journal of the Neurological Sciences·J K McGeachieJ E Morgan
Aug 1, 1993·Experimental Cell Research·T A RobertsonJ M Papadimitriou

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Citations

Aug 14, 1998·Muscle & Nerve·J E AndersonK Penner
May 14, 2003·Experimental Gerontology·Alban VignaudArnaud Ferry
Feb 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Elliott HillDavid J Mooney
Sep 3, 2010·The Journal of Biological Chemistry·Ling ZengKenneth Walsh
Nov 15, 2007·Stem Cells and Development·Sander GrefteJohannes W Von den Hoff
Jun 15, 2006·Tissue Engineering·Elliott HillDavid J Mooney
Feb 21, 1998·Australian Dental Journal·J McGeachie, M Tennant
Feb 26, 2011·Journal of Tissue Engineering·Ye-Rang YunHae-Won Kim
Jan 14, 2012·Physical Medicine and Rehabilitation Clinics of North America·Joe N KornegayKathryn R Wagner
Jan 1, 2012·ISRN Orthopedics·L BaogeL C Vanden Bossche
May 8, 2009·Orthodontics & Craniofacial Research·L S HollidayC Dolce
Apr 5, 2013·Journal of Tissue Engineering and Regenerative Medicine·Koki HagiwaraHiroaki Komuro
May 5, 2010·Animal Science Journal = Nihon Chikusan Gakkaihō·Takahiro SuzukiRyuichi Tatsumi
Jun 12, 2001·Clinics in Sports Medicine·V MartinekJ Huard
Jan 23, 2003·The Journal of Gene Medicine·Johnny HuardFreddie H Fu
Dec 13, 2006·Cells, Tissues, Organs·Ulrich Reinhart GoesslerFrank Riedel
Jan 1, 2012·Stem Cells International·Umile Giuseppe LongoVincenzo Denaro
Apr 27, 2005·The American Journal of Sports Medicine·Tero A H JärvinenMarkku Järvinen
Jan 1, 1997·The Australian and New Zealand Journal of Surgery·M J Lawson-Smith, J K McGeachie
Feb 3, 1999·Annals of the New York Academy of Sciences·M D Grounds
Jan 1, 1997·Growth Factors·L AustinC M Muldoon
Oct 1, 2019·Journal of Cellular and Molecular Medicine·Felicia CarotenutoPaolo Di Nardo
Jan 13, 2004·Physiological Reviews·Sophie B P Chargé, Michael A Rudnicki
Mar 30, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P DesgrangesJ Gautron
Jan 25, 2000·American Journal of Physiology. Cell Physiology·K J MillerG K Pavlath
Feb 8, 2000·Clinical Orthopaedics and Related Research·C KasemkijwattanaJ Huard
Jul 18, 2001·Journal of Applied Physiology·T J Hawke, D J Garry
Jan 23, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mahroo MofarrahiSabah N A Hussain

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