PMID: 8603103Mar 27, 1996Paper

The exon encoding the fibronectin type III-9 repeat is constitutively included in the mRNA from chick limb mesenchyme and cartilage

Biochimica Et Biophysica Acta
A L GehrisV D Bennett

Abstract

The fibronectin monomer is comprised of three types of homologous repeating units, the types I, II, and III elements. Each type III repeat is encoded by two exons except for the two type III repeats involved in alternative splicing (IIIB and IIIA) and the type III-9 repeat which are all encoded by one exon. The fact that the type III-9 repeat is the only other type III repeat encoded by one exon has led to speculation that this exon may also be alternatively spliced. However, no evidence exists for alternative splicing of this exon in any tissues examined to date. The recent localization of a cell adhesion synergy site within the type III-9 repeat increases the likelihood of functional ramifications if the exon encoding this repeat is alternatively spliced in specific cells or tissues. We have shown previously that chick cartilage contains an unusual fibronectin mRNA splicing pattern and that the pattern changes during chondrogenesis from B+A+V+ to B+A-V+. In order to completely characterize the fibronectin mRNA in cartilage and other mesenchymal tissues for all possible alternative splicing events, we have determined whether or not the exon encoding the type III-9 repeat is alternatively spliced in these tissues. RNase protect...Continue Reading

References

Oct 1, 1977·Developmental Biology·P B AhrensR S Reiter
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Jun 1, 1992·Clinical Biochemistry·K E Kuettner
Jul 25, 1990·Nucleic Acids Research·P A Norton, R O Hynes
Nov 20, 1987·Biochimica Et Biophysica Acta·S KubomuraH Hirano
Dec 1, 1987·Molecular and Cellular Biology·P A Norton, R O Hynes
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·E OdermattR O Hynes
Dec 31, 1982·Biochemical and Biophysical Research Communications·N B Wurster, G Lust
Sep 1, 1993·Molecular and Cellular Biology·G S Huh, R O Hynes

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Citations

Mar 1, 1997·Matrix Biology : Journal of the International Society for Matrix Biology·N Burton-WursterJ N Macleod
Aug 26, 1998·Matrix Biology : Journal of the International Society for Matrix Biology·N Burton-WursterJ N Macleod
Apr 1, 2004·Birth Defects Research. Part C, Embryo Today : Reviews·Audrey McAlindenLinda J Sandell

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