The expanding constellation of immune checkpoints: a DNAMic control by CD155

The Journal of Clinical Investigation
Vincenzo Bronte

Abstract

The clinical benefits that have been achieved for a group of cancer patients with metastatic disease on checkpoint inhibitor therapy have kindled intense interest in understanding tumor-induced escape from T lymphocyte control. Other lymphoid cells also participate in tumor control; in particular, NK cells can limit hematogenous cancer metastasis spread and are also subject to negative regulation by developing cancers. In this issue of the JCI, Li and colleagues define an unanticipated role for the stress-induced protein CD155 in cancer metastasis. The presence of CD155 on the surface of cancer cells was shown to promote tumor invasiveness, while its upregulation in tumor environment-infiltrating myeloid cells restrained antitumor immunity by impairing antitumor T lymphocytes and NK cell function. Together, these results support further exploration of strategies for targeting CD155.

References

Aug 30, 2013·Science Translational Medicine·Stefani SprangerThomas F Gajewski
Aug 16, 2017·Cancer Cell·Alejandro López-SotoLorenzo Galluzzi
Oct 27, 2017·Nature·Martina MolgoraAlberto Mantovani
Jan 18, 2018·The Journal of Clinical Investigation·Haidong TangYang-Xin Fu
Mar 8, 2018·Journal for Immunotherapy of Cancer·Priyanka B SubrahmanyamF Stephen Hodi
Apr 3, 2018·The Journal of Clinical Investigation·Heng LinWeiping Zou
May 15, 2018·The Journal of Clinical Investigation·Xian-Yang LiMark J Smyth

❮ Previous
Next ❯

Citations

Oct 3, 2018·Cellular & Molecular Immunology·Paola Kučan BrlićStipan Jonjić
Jan 26, 2021·Frontiers in Molecular Biosciences·Kaikai ZhaoJinming Yu
Aug 10, 2021·Frontiers in Oncology·Xi-Yang TangJin-Bo Zhao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

© 2022 Meta ULC. All rights reserved