The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction

Molecular Immunology
Anne F McGettrick, Luke A J O'Neill

Abstract

Toll-like receptors (TLRs) play an essential role in the detection and elimination of invading microbes. They are type-1 transmembrane receptors, containing extracellular leucine rich repeats and an intracellular Toll/interleukin-1 receptor (TIR) domain. Upon stimulation, these receptors interact with specific TIR domain-containing adaptor proteins. Five such adaptors have been discovered to date, MyD88, Mal (MyD88 adaptor-like)/TIRAP (TIR domain-containing adaptor protein), Trif (TIR-domain-containing adaptor inducing interferon-beta), TRAM (Trif-related adaptor molecule) and SARM (SAM and ARM-containing protein). Different TLRs use different combinations of these adaptors, leading to the activation of common and unique pathways involved in the elimination of the invading microbe.

Citations

Jan 22, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Xiaoxia Li, Jinzhong Qin
Aug 7, 2010·Intensive Care Medicine·Emmanuel LorneEdward Abraham
Mar 3, 2010·Immunogenetics·Qing ZhangAdam Godzik
Nov 12, 2005·Archives of Dermatological Research·Adone BaroniElisabetta Buommino
Jun 12, 2013·Developmental and Comparative Immunology·P T LeeC J Secombes
Nov 12, 2005·Parasitology·H S Goodridge, M M Harnett
Aug 21, 2007·Nature Cell Biology·Asya RollsMichal Schwartz
Jul 20, 2007·Immunology and Cell Biology·Ashish Banerjee, Steve Gerondakis
Jun 22, 2007·Organic & Biomolecular Chemistry·Mahalakshmi VasanGeert-Jan Boons
Jun 11, 2009·The Journal of Biological Chemistry·Kamalpreet NagpalDouglas T Golenbock
Feb 7, 2009·The Journal of Biological Chemistry·Girish K RadhakrishnanGary A Splitter
Mar 17, 2007·Annual Review of Biochemistry·Nicholas J Gay, Monique Gangloff
Mar 18, 2005·Annual Review of Immunology·Argyrios N TheofilopoulosDwight H Kono
May 9, 2006·Genome Biology·Leah McHaleRichard W Michelmore
Aug 6, 2008·Genome Biology·Qing ZhangAdam Godzik
Dec 10, 2009·PLoS Pathogens·Victoria AuerbuchRalph R Isberg
Jun 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Anne F McGettrickLuke A J O'Neill
Aug 24, 2007·Expert Opinion on Investigational Drugs·Ziad Thotathil, Michael B Jameson
Jan 27, 2016·Applied Biochemistry and Biotechnology·Shudong NiuXianghong Xiao
Feb 18, 2016·BioMed Research International·Gi-Su OhHong-Seob So
Aug 7, 2010·Trends in Cell Biology·Rita TewariJuliet C Coates
Jan 12, 2010·Current Opinion in Immunology·Anne F McGettrick, Luke A J O'Neill
Oct 24, 2009·Veterinary Immunology and Immunopathology·Alexander ReblHans-Martin Seyfert
Sep 11, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Zhuohan ZhangRongcun Yang
Oct 30, 2015·The International Journal of Biochemistry & Cell Biology·A MateuI De Dios
Nov 6, 2007·Molecular Immunology·Loh Wei-Ching BelindaDing Jeak Ling
Jul 3, 2007·Veterinary Immunology and Immunopathology·King S NalubambaJohn Hopkins
Nov 17, 2006·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Sachiko Akashi-Takamura, Kensuke Miyake
Sep 28, 2007·British Journal of Haematology·Anne F McGettrick, Luke A J O'Neill
Oct 8, 2008·European Journal of Clinical Investigation·C ErridgeD J Webb
Sep 13, 2006·Parasite Immunology·W Harnett, M M Harnett

❮ Previous
Next ❯

Related Concepts

Related Feeds

Absence Epilepsy

Absence epilepsy is a common seizure disorder in children which can produce chronic psychosocial sequelae. Discover the latest research on absence epilepsies here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Nicole T LiberatiFrederick M Ausubel
© 2022 Meta ULC. All rights reserved