The Expanding Prominence of Toxic Leukoencephalopathy

The Journal of Neuropsychiatry and Clinical Neurosciences
Christopher M FilleyC Alan Anderson

Abstract

Toxic leukoencephalopathy (TL) is a disorder of brain white matter caused by exposure to leukotoxic agents. Magnetic resonance imaging (MRI) can readily identify this syndrome, and, together with diffusion tensor imaging, MRI continues to offer important insights into its nature. Since the first formal description of TL in 2001, many new leukotoxic disorders have been recognized, and the range of leukotoxins has expanded to include more therapeutic drugs, drugs of abuse, and environmental insults. While the understanding of pathophysiology remains incomplete, TL is increasingly common in clinical practice, and the potential long-term cognitive sequelae of toxic white matter injury merit attention.

Citations

Nov 6, 2018·Journal of Addiction Medicine·Anouk M J van EschArnt F A Schellekens
Aug 15, 2019·Journal of Investigative Medicine High Impact Case Reports·Edward C MaderLionel A Branch
Jun 17, 2020·Journal of the International Neuropsychological Society : JINS·Dana M SzelesAndreana Benitez
Nov 10, 2020·Curēus·Mustafa Al-ChalabiMalik Ghannam
Apr 23, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicholas S PhillipsNicole J Ullrich
May 28, 2021·Practical Neurology·Yue Hui LauShanthi Viswanathan
Jun 9, 2021·Journal of the Academy of Consultation-Liaison Psychiatry·Heather BurkeAlexis Cohen-Oram
Dec 18, 2020·Revista colombiana de psiquiatría·Sergio Andrés Ochoa-OrozcoJulián David Carvajal-Guevara

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