The expanding role of neurosurgeons in the management of brain metastases

Surgical Neurology
Jason SheehanL Dade Lunsford

Abstract

Brain metastases are the most common type of intracranial tumor. Until recently, whole brain fractionated radiation therapy (WBRT) was the mainstay of treatment, thereby confining the role of neurosurgeons to resection of an occasional solitary, accessible, and symptomatic brain metastasis. Median survival after surgery and radiation typically ranged from 5 to 11 months. We analyzed various demographic incidence reports and our series of brain metastasis patients treated with radiosurgery. During a 15-year interval (1987-2002), radiosurgery was performed on 5,032 patients of whom 1,088 (21.6%) had metastatic brain tumors. In the United States, 266,820 to 533,640 new cases of brain metastases will be diagnosed in the year 2003. Evidence to date demonstrates that radiosurgery provides effective local tumor control for brain metastases. Important prognostic factors affecting patient survival include the absence of active systemic disease, the patient's preoperative performance status, age, and the number of metastases. Survival and local tumor control rates attained with radiosurgery are superior to those of either conventional surgery or WBRT. The morbidity associated with radiosurgery of brain metastasis is very low, and the mor...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·M P MehtaT J Kinsella
Feb 1, 1992·Journal of Neuro-oncology·J L CaronE B Podgorsak
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·L R CoiaT J Priestman
Mar 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G StevensA Coates
Jun 1, 1991·International Journal of Radiation Oncology, Biology, Physics·R J CoffeyL D Lunsford
Mar 1, 1992·Journal of Neurosurgery·J R AdlerD P Martin
Jul 1, 1990·International Journal of Radiation Oncology, Biology, Physics·P J HoskinH T Ford
Feb 22, 1990·The New England Journal of Medicine·R A PatchellB Young
Mar 1, 1989·International Journal of Radiation Oncology, Biology, Physics·M Diener-WestD F Nelson
Jul 1, 1988·International Journal of Radiation Oncology, Biology, Physics·A SadeghiT Lad
Jul 1, 1988·Archives of Neurology·J Y DelattreJ B Posner
Oct 1, 1986·The Annals of Thoracic Surgery·D J MagilliganJ I Ausman
Feb 1, 1971·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·L Z NisceF C Chu
Mar 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D A DeckerG D Cummings
Jun 1, 1980·Annals of Neurology·J G CairncrossJ B Posner
Jan 4, 1995·Journal of the National Cancer Institute·E AlexanderJ S Loeffler
Oct 1, 1995·Journal of Neurosurgery·R K BindalS H Taylor
Jan 1, 1993·Stereotactic and Functional Neurosurgery·L KihlströmC Lindquist
Mar 1, 1994·International Journal of Radiation Oncology, Biology, Physics·J C FlickingerP K Sneed
Aug 1, 1993·Journal of Neurosurgery·R K BindalJ J Lee
Nov 1, 1993·Journal of Neurosurgery·S SomazaJ C Flickinger
Jun 1, 1993·Annals of Neurology·C J VechtA R Wattendorff
Apr 1, 1996·International Journal of Radiation Oncology, Biology, Physics·R M AuchterM P Mehta
Jan 1, 1997·Radiation Oncology Investigations·E Fernandez-ViciosoG H Barnett
Feb 5, 1998·CA: a Cancer Journal for Clinicians·S H LandisP A Wingo
Nov 7, 1998·International Journal of Radiation Oncology, Biology, Physics·Y MoriL D Lunsford
Oct 3, 1999·Journal of Neurosurgery·C F HuangL D Lunsford
Mar 17, 2000·Neurosurgery·A Niranjan, L D Lunsford
Jun 15, 2000·Stereotactic and Functional Neurosurgery·T P ThompsonD Kondziolka
Jun 23, 2000·Annals of Surgical Oncology·K S FirlikL D Lunsford
Oct 31, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G SimonováJ Novotný
Feb 21, 2002·Neurosurgery·Douglas KondziolkaL Dade Lunsford
Mar 9, 2002·Journal of Neurosurgery·Vincenzo MingioneLadislau Steiner
Jun 14, 2002·International Journal of Radiation Oncology, Biology, Physics·Penny K SneedMinesh P Mehta
Aug 22, 2002·Neurosurgery·Paul D BrownRobert L Foote

❮ Previous
Next ❯

Citations

Apr 26, 2014·Journal of Cancer Research and Therapeutics·Alessandro AgnolettiDiego Garbossa
May 26, 2005·Cancer Treatment Reviews·Konstantinos S PolyzoidisNicholas Pavlidis
Jul 5, 2007·Neurosurgical Focus·Anthony L D'Ambrosio, Siviero Agazzi
Dec 3, 2009·Neurosurgical Focus·Jason Sheehan, Nader Pouratian
Oct 25, 2007·Neurosurgical Review·Marcos Vinícius Calfat MaldaunRaymond Sawaya
May 22, 2010·Neurosurgical Review·Nikolay A PeevHirotoshi Sano
Apr 14, 2009·Journal of Neurosurgery·Jay JagannathanJason P Sheehan
Jan 9, 2010·International Journal of Radiation Oncology, Biology, Physics·Ajay NiranjanL Dade Lunsford
Mar 10, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Wen-Yuen LeeLi-Hwei Ho
Feb 6, 2007·International Journal of Radiation Oncology, Biology, Physics·Mikhail F ChernovKintomo Takakura
Jan 31, 2012·Stereotactic and Functional Neurosurgery·Maryam RahmanWilliam A Friedman
Jan 30, 2007·Stereotactic and Functional Neurosurgery·Johnathan A EnghL Dade Lunsford
Jun 2, 2007·NMR in Biomedicine·Torill E SjøbakkIngrid S Gribbestad
Mar 30, 2007·Acta Paediatrica. Supplement·Steven U Walkley
Oct 21, 2005·Neurosurgery·Minesh P Mehta, Deepak Khuntia
Oct 6, 2006·Journal of Neuropathology and Experimental Neurology·Mark W BecherLarry E Davis
Oct 15, 2019·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Or Cohen-Inbar
Oct 21, 2005·Neurosurgery·Robert J YoungEdmond A Knopp
Oct 26, 2005·Journal of Neuro-oncology·R Deinsberger, J Tidstrand
May 29, 2018·World Neurosurgery·Domenico A GattozziRoukoz B Chamoun

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.