The expanding spectrum of paroxysmal movement disorders: update from clinical features to therapeutics

Current Opinion in Neurology
Eavan M McGovernTimothy J Counihan

Abstract

This review will discuss the expanding clinical spectrum of paroxysmal movement disorders and therapeutic options in light of emerging genotypic heterogeneity in these conditions. Paroxysmal movement disorders comprise a heterogeneous group of rare neurological conditions characterized by intermittent episodes of abnormal movement associated with various triggers. As the clinical and genotypic spectrum of these disorders evolves, so also has the range of therapeutic options. Triheptanoin has recently been shown to be a very promising alternative to the ketogenic diet in paroxysmal exercise-induced dyskinesia. Four-aminopyridine is now considered first-line symptomatic therapy for episodic ataxia type-2, with pre-clinical findings indicating cerebellar neuroprotection. In light of the newly emerging therapies, careful clinical phenotyping is needed to ensure diagnostic precision and timely initiation of appropriate therapies.

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Citations

Mar 13, 2020·Annals of Clinical and Translational Neurology·Julie PiarrouxAgathe Roubertie
May 24, 2020·International Journal of Molecular Sciences·Giacomo GaroneFrancesco Nicita
Jun 13, 2019·Current Neurology and Neuroscience Reports·Zheyu XuEng-King Tan
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Apr 14, 2020·Neurologic Clinics·Anna Latorre, Kailash P Bhatia
Jul 3, 2021·Journal of Clinical Medicine·Giacomo GaroneAlessandro Capuano

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