The expanding spectrum of thalassemia intermedia

Hematology
I PanigrahiKetan Kulkarni

Abstract

The hemoglobin disorders serve as a model for study of the genetic heterogeneity underlying the phenotype of genetic disorders. 'Thalassemia intermedia' is a clinical phenotype which displays marked genotypic variability in different populations or ethnic groups. Two common underlying mechanisms include co-inheritance of alpha globin gene deletions in homozygous thalassemia intermedia and presence of XmnI polymorphism. The newly described mechanisms including unstable hemoglobin disorders and somatic deletions in beta-globin gene are elaborated in the present review.

References

Feb 1, 1992·British Journal of Haematology·A MeloniA Vitucci
Mar 1, 1993·Baillière's Clinical Haematology·D R Higgs
Mar 1, 1993·Baillière's Clinical Haematology·S L Thein
Sep 18, 2001·American Journal of Hematology·A NadkarniD Mohanty
Jan 26, 2002·Lancet·C BadensD Lena-Russo
Feb 27, 2003·Hemoglobin·Ramachandran V ShajiAlok Srivastava
Aug 17, 2005·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Adekunle AdekileFerdane Kutlar
Nov 11, 2006·Acta Haematologica·G D EfremovG H Petkov
May 9, 2007·Hemoglobin·Georgi D Efremov
Oct 23, 2008·Genetic Testing·Maryam NeishaburyHossein Najmabadi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.